%0 Journal Article %A Lacret, Rodney %A Oves-Costales, Daniel %A Pérez-Victoria, Ignacio %A de la Cruz, Mercedes %A Díaz, Caridad %A Vicente, Francisca %A Genilloud, Olga %A Reyes, Fernando %D 2018 %T MDN-0171, a new medermycin analogue from Streptomyces albolongus CA-186053 %U https://tandf.figshare.com/articles/journal_contribution/MDN-0171_a_new_medermycin_analogue_from_i_Streptomyces_albolongus_i_CA-186053/5863677 %R 10.6084/m9.figshare.5863677.v1 %2 https://tandf.figshare.com/ndownloader/files/10415886 %K Medermycin %K pyranonaphthoquinone %K Streptomyces albolongus %K marine natural products %K structural elucidation %X

A new medermycin derivative, MDN-0171 (1), and two known structurally related compounds, medermycin (2) and antibiotic G15-F (3) were isolated from the acetone extract of culture broths of the marine-derived Streptomyces albolongus strain CA-186053. Their structures were determined using a combination of spectroscopic techniques, including 1D and 2D NMR and electrospray-time of flight mass spectrometry (ESI-TOF MS). Compounds 2 and 3 accounted for the antimicrobial activity (against methicillin-resistant Staphylococcus aureus and Escherichia coli) previously detected in the crude extract of this actinomycete.

%I Taylor & Francis