10.6084/m9.figshare.5882722.v1
Lin Zhao
Lin
Zhao
Yifang Zhu
Yifang
Zhu
Zhangjian Chen
Zhangjian
Chen
Huadong Xu
Huadong
Xu
Jingwen Zhou
Jingwen
Zhou
Shichuan Tang
Shichuan
Tang
Zhizhen Xu
Zhizhen
Xu
Fanling Kong
Fanling
Kong
Xinwei Li
Xinwei
Li
Yifei Zhang
Yifei
Zhang
Xianzuo Li
Xianzuo
Li
Ji Zhang
Ji
Zhang
Guang Jia
Guang
Jia
Cardiopulmonary effects induced by occupational exposure to titanium dioxide nanoparticles
Taylor & Francis Group
2018
Nanoparticles
nanotoxicology
occupational health
cardiovascular diseases
pulmonary function
2018-02-13 14:32:36
Journal contribution
https://tandf.figshare.com/articles/journal_contribution/Cardiopulmonary_effects_induced_by_occupational_exposure_to_titanium_dioxide_nanoparticles/5882722
<p>Although some toxicological studies have reported that exposure to titanium dioxide nanoparticles (nano-TiO<sub>2</sub>) may elicit adverse cardiopulmonary effects, related data collected from human are currently limited. The purpose of this study is to explore cardiopulmonary effects among workers who were exposed to nano-TiO<sub>2</sub> and to identify biomarkers associated with exposure. A cross-sectional study was conducted in a nano-TiO<sub>2</sub> manufacturing plant in eastern China. Exposure assessment and characterization of TiO<sub>2</sub> particles were performed in a packaging workshop. Physical examination and possible biomarkers for cardiopulmonary effects were examined among 83 exposed workers and 85 controls. In packaging workshop, the total mass concentration of particles was 3.17 mg/m<sup>3</sup>. The mass concentration of nanoparticles was 1.22 mg/m<sup>3</sup> accounting for 39% of the total mass. Lung damage markers (SP-D and pulmonary function), cardiovascular disease markers (VCAM-1, ICAM-1, LDL, and TC), oxidative stress markers (SOD and MDA), and inflammation markers (IL-8, IL-6, IL-1β, TNF-α, and IL-10) were associated with occupational exposure to nano-TiO<sub>2</sub>. Among those markers, SP-D showed a time (dose)–response pattern within exposed workers. The data strongly suggest that nano-TiO<sub>2</sub> could contribute, at least in part, to the cardiopulmonary effects observed in workers. The studied markers and pulmonary function tests may be useful in health surveillance for workers exposed to nanomaterials.</p>