10.6084/m9.figshare.5901583.v1 Dedi Satria Dedi Satria Yhiya Amen Yhiya Amen Yasuharu Niwa Yasuharu Niwa Ahmed Ashour Ahmed Ashour Ahmed E. Allam Ahmed E. Allam Kuniyoshi Shimizu Kuniyoshi Shimizu Lucidumol D, a new lanostane-type triterpene from fruiting bodies of Reishi (<i>Ganoderma lingzhi</i>) Taylor & Francis Group 2018 Lucidumol D Ganoderma lingzhi triterpene cytotoxicity 2018-02-19 15:59:54 Journal contribution https://tandf.figshare.com/articles/journal_contribution/Lucidumol_D_a_new_lanostane-type_triterpene_from_fruiting_bodies_of_Reishi_i_Ganoderma_lingzhi_i_/5901583 <p>A new lanostane-type triterpenoid, lucidumol D (<b>1</b>) was isolated from the fruiting bodies of <i>Ganoderma lingzhi</i>. Its structure was elucidated on the basis of extensive 1D- and 2D-NMR studies as well as mass spectrometry. The cytotoxicity of lucidumol D against proliferation of several cancer cells were assayed by using MTT method and the obtained result suggested selective anti-proliferative and cytotoxic effects against MCF-7, HepG2, HeLa, Caco-2, and HCT-116. In comparison to lucidumol C (<b>2</b>) isolated previously by our group, the structure-activity relationship indicated that carbonyl function at C-11 is necessary to enhance the cytotoxicity.</p>