10.6084/m9.figshare.5901583.v1
Dedi Satria
Dedi
Satria
Yhiya Amen
Yhiya
Amen
Yasuharu Niwa
Yasuharu
Niwa
Ahmed Ashour
Ahmed
Ashour
Ahmed E. Allam
Ahmed E.
Allam
Kuniyoshi Shimizu
Kuniyoshi
Shimizu
Lucidumol D, a new lanostane-type triterpene from fruiting bodies of Reishi (<i>Ganoderma lingzhi</i>)
Taylor & Francis Group
2018
Lucidumol D
Ganoderma lingzhi
triterpene
cytotoxicity
2018-02-19 15:59:54
Journal contribution
https://tandf.figshare.com/articles/journal_contribution/Lucidumol_D_a_new_lanostane-type_triterpene_from_fruiting_bodies_of_Reishi_i_Ganoderma_lingzhi_i_/5901583
<p>A new lanostane-type triterpenoid, lucidumol D (<b>1</b>) was isolated from the fruiting bodies of <i>Ganoderma lingzhi</i>. Its structure was elucidated on the basis of extensive 1D- and 2D-NMR studies as well as mass spectrometry. The cytotoxicity of lucidumol D against proliferation of several cancer cells were assayed by using MTT method and the obtained result suggested selective anti-proliferative and cytotoxic effects against MCF-7, HepG2, HeLa, Caco-2, and HCT-116. In comparison to lucidumol C (<b>2</b>) isolated previously by our group, the structure-activity relationship indicated that carbonyl function at C-11 is necessary to enhance the cytotoxicity.</p>