%0 Journal Article %A Satria, Dedi %A Amen, Yhiya %A Niwa, Yasuharu %A Ashour, Ahmed %A Allam, Ahmed E. %A Shimizu, Kuniyoshi %D 2018 %T Lucidumol D, a new lanostane-type triterpene from fruiting bodies of Reishi (Ganoderma lingzhi) %U https://tandf.figshare.com/articles/journal_contribution/Lucidumol_D_a_new_lanostane-type_triterpene_from_fruiting_bodies_of_Reishi_i_Ganoderma_lingzhi_i_/5901583 %R 10.6084/m9.figshare.5901583.v1 %2 https://tandf.figshare.com/ndownloader/files/10526230 %K Lucidumol D %K Ganoderma lingzhi %K triterpene %K cytotoxicity %X

A new lanostane-type triterpenoid, lucidumol D (1) was isolated from the fruiting bodies of Ganoderma lingzhi. Its structure was elucidated on the basis of extensive 1D- and 2D-NMR studies as well as mass spectrometry. The cytotoxicity of lucidumol D against proliferation of several cancer cells were assayed by using MTT method and the obtained result suggested selective anti-proliferative and cytotoxic effects against MCF-7, HepG2, HeLa, Caco-2, and HCT-116. In comparison to lucidumol C (2) isolated previously by our group, the structure-activity relationship indicated that carbonyl function at C-11 is necessary to enhance the cytotoxicity.

%I Taylor & Francis