Legname, Giuseppe Virgilio, Tommaso Bistaffa, Edoardo De Luca, Chiara Maria Giulia Catania, Marcella Zago, Paola Isopi, Elisa Campagnani, Ilaria Tagliavini, Fabrizio Giaccone, Giorgio Moda, Fabio Effects of peptidyl-prolyl isomerase 1 depletion in animal models of prion diseases <p>Pin1 is a peptidyl-prolyl isomerase that induces the <i>cis-trans</i> conversion of specific Ser/Thr-Pro peptide bonds in phosphorylated proteins, leading to conformational changes through which Pin1 regulates protein stability and activity. Since down-regulation of Pin1 has been described in several neurodegenerative disorders, including Alzheimer's Disease (AD), Parkinson's Disease (PD) and Huntington's Disease (HD), we investigated its potential role in prion diseases. Animals generated on wild-type (Pin1<sup>+/+</sup>), hemizygous (Pin1<sup>+/−</sup>) or knock-out (Pin1<sup>−/−</sup>) background for Pin1 were experimentally infected with RML prions. The study indicates that, neither the total depletion nor reduced levels of Pin1 significantly altered the clinical and neuropathological features of the disease.</p> Pin1;prion;PMCA;neurodegeneration 2018-04-20
    https://tandf.figshare.com/articles/dataset/Effects_of_peptidyl-prolyl_isomerase_1_depletion_in_animal_models_of_prion_diseases/6165845
10.6084/m9.figshare.6165845.v1