10.6084/m9.figshare.6171026.v1 Min-Hong Jiang Min-Hong Jiang Yue Hu Yue Hu Lin Jiao Lin Jiao Pan Dong Pan Dong Sheng Yin Sheng Yin Zhi-Min Zhao Zhi-Min Zhao De-Po Yang De-Po Yang Dong-Mei Wang Dong-Mei Wang A new labdane-type diterpenoid from <i>Leonurus japonicus</i> Taylor & Francis Group 2018 Labiatae Leonurus japonicus labdane-type diterpenoids cytotoxic activity 2018-04-23 13:44:19 Journal contribution https://tandf.figshare.com/articles/journal_contribution/A_new_labdane-type_diterpenoid_from_i_Leonurus_japonicus_i_/6171026 <p>Five fractions prepared from the crude extract of <i>Leonurus japonicus</i> were examined in order to determine their cytotoxic potential. Under the bioassay guidance, a new labdane-type diterpenoid (<b>1</b>), and nine known ones (<b>2–10</b>) along with a <i>seco</i>-labdane (<b>11</b>) were isolated from the aerial parts of <i>Leonurus japonicus</i>. The structure elucidation was primarily based on comprehensive spectroscopic analyses, including HRESIMS, IR, and 1D and 2D NMR methods. Compound <b>4</b> (6β-hydroxy-15,16-epoxylabda-8,13(16),14-trien-7-one) exhibited potential cytotoxicity against HeLa cell line (IC<sub>50</sub> = 23.75 μM).</p>