Rana, Neha Kumar, Manish Singh, Ankita Maity, Jyotirmoy Shukla, Poonam Prasad, Ashok K. Synthesis of novel 3′-azido-3′-deoxy-α-L-<i>ribo</i> configured nucleosides: A comparative study between chemical and chemo-enzymatic methodologies <p></p> <p>Syntheses of novel 3′-azido-3′-deoxy-2′-<i>O</i>,4′-<i>C</i>-methylene-<i>α-</i>L-<i>ribo</i>furanosyl nucleosides have been carried out from 3′-azido-3′-deoxy-4′-<i>C</i>-hydroxymethyl-β-D-<i>xylo</i>furanosyl nucleosides following both chemical and chemo-enzymatic methodologies. The precursor nucleoside in turn was synthesized from a common glycosyl donor 4-<i>C</i>-acetoxymethyl-1,2,5-tri-<i>O</i>-acetyl-3-azido-3-deoxy-<i>α,β</i>-D-<i>xylo</i>furanose, which was obtained by the acetolysis of 4-<i>C</i>-acetoxymethyl-5-<i>O</i>-acetyl-3-azido-3-deoxy-1,2-<i>O</i>-isopropylidene-α-D-<i>xylo</i>furanose in 96% yield. It has been observed that a chemo-enzymatic pathway for the synthesis of targeted nucleosides is much more efficient than a chemical pathway, leading to the improvement in yield for the synthesis of 3′-azido-3′-deoxy-<i>α-</i>L-<i>ribo</i>furanosyl thymine and uracil from 49 to 89% and 55 to 93%, respectively.</p> diastereoselective;biocatalysis;novozyme®-435;3′-azido-3′-deoxy-α-L-ribofuranosyl nucleosides 2018-05-03
    https://tandf.figshare.com/articles/journal_contribution/Synthesis_of_novel_3_-azido-3_-deoxy-_-L-_i_ribo_i_configured_nucleosides_A_comparative_study_between_chemical_and_chemo-enzymatic_methodologies/6217514
10.6084/m9.figshare.6217514.v1