Lee, Jason K. H. Lam, Gary K. L. Shin, Thomas Kim, Jiyeon Krishnan, Anish Greenberg, David P. Chit, Ayman Efficacy and effectiveness of high-dose versus standard-dose influenza vaccination for older adults: a systematic review and meta-analysis <p><b>Background</b>: Influenza is responsible for a significant disease burden annually, especially in older adults. This study reviews the relative vaccine efficacy or effectiveness (rVE) of high-dose inactivated trivalent influenza vaccine (HD-IIV3) compared to standard-dose influenza vaccines (SD-IIV3) in adults ≥65 against influenza-associated outcomes to inform evidence-based decision-making to shift clinical practice and standard of care in this population.</p> <p><b>Methods</b>: A systematic review was conducted for studies assessing the rVE of HD-IIV3 against probable/laboratory-confirmed influenza-like illness (ILI), hospital admissions, and death in adults ≥65. Results from individual seasons were meta-analyzed and a random-effects model was used to estimate pooled rVEs.</p> <p><b>Results</b>: After screening 992 studies, seven studies were meta-analyzed. HD-IIV3 demonstrated better protection against ILI compared to SD-IIV3 (rVE = 19.5%; 95% CI: 8.6–29.0%). HD-IIV3 was also more effective at preventing hospital admissions from all-causes (rVE = 9.1%; 95% CI: 2.4–15.3%), as well as from influenza (rVE = 17.8%; 95% CI: 8.1–26.5%), pneumonia (rVE = 24.3%, 95% CI: 13.9–33.4%), and cardiorespiratory events (rVE = 18.2%; 95% CI: 6.8–28.1%). rVE against post-influenza mortality was 22.2% (95% CI: -18.2–48.8%) and 2.5% (95% CI: -5.2–9.5%) against all-cause mortality.</p> <p><b>Conclusions</b>: Available evidence suggests HD-IIV3 is more effective than SD-IIV3 at reducing the clinical outcomes associated with influenza infection in older adults and should be considered for routine use in the 65+ population.</p> High dose influenza vaccine;influenza;seniors;elderly;efficacy;effectiveness;hospitalization;death;systematic review;meta-analysis 2018-05-16
    https://tandf.figshare.com/articles/journal_contribution/Efficacy_and_effectiveness_of_high-dose_versus_standard-dose_influenza_vaccination_for_older_adults_a_systematic_review_and_meta-analysis/6279131
10.6084/m9.figshare.6279131.v1