10.6084/m9.figshare.6293384.v1 Sophie E. Heethuis Sophie E. Heethuis Lucas Goense Lucas Goense Peter S. N. van Rossum Peter S. N. van Rossum Alicia S. Borggreve Alicia S. Borggreve Stella Mook Stella Mook Francine E. M. Voncken Francine E. M. Voncken Annemarieke Bartels-Rutten Annemarieke Bartels-Rutten Berthe M. P. Aleman Berthe M. P. Aleman Richard van Hillegersberg Richard van Hillegersberg Jelle P. Ruurda Jelle P. Ruurda Gert J. Meijer Gert J. Meijer Jan J. W. Lagendijk Jan J. W. Lagendijk Astrid L. H. M. W. van Lier Astrid L. H. M. W. van Lier DW-MRI and DCE-MRI are of complementary value in predicting pathologic response to neoadjuvant chemoradiotherapy for esophageal cancer Taylor & Francis Group 2018 five patients underwent concentration time curve 49 %) patients investigated .</ p 89 ).</ p trg ≤ 2 predicting pathologic response pre </ sub predicting response pre ), potential benefit p90 δauc neoadjuvant chemoradiotherapy good response esophageal cancer dynamic contrast complementary value 79 ). 75th percentile 75 ). 2018-05-21 11:52:52 Dataset https://tandf.figshare.com/articles/dataset/DW-MRI_and_DCE-MRI_are_of_complementary_value_in_predicting_pathologic_response_to_neoadjuvant_chemoradiotherapy_for_esophageal_cancer/6293384 <p>To explore the potential benefit and complementary value of a multiparametric approach using diffusion-weighted (DW-) and dynamic contrast-enhanced (DCE-) magnetic resonance imaging (MRI) for prediction of response to neoadjuvant chemoradiotherapy (nCRT) in esophageal cancer.</p> <p>Forty-five patients underwent both DW-MRI and DCE-MRI prior to nCRT (pre), during nCRT (week 2–3) (per) and after completion of nCRT, but prior to esophagectomy (post). Subsequently, histopathologic tumor regression grade (TRG) was assessed. Tumor apparent diffusion coefficient (ADC) and area-under-the-concentration time curve (AUC) were calculated for DW-MRI and DCE-MRI, respectively. The ability of these parameters to predict pathologic complete response (pCR, TRG1) or good response (GR, TRG ≤ 2) to nCRT was assessed. Furthermore the complementary value of DW-MRI and DCE-MRI was investigated.</p> <p>GR was found in 22 (49%) patients, of which 10 (22%) patients showed pCR. For DW-MRI, the 75th percentile (P75) ΔADC<sub>post-pre</sub> was most predictive for GR (c-index = 0.75). For DCE-MRI, P90 ΔAUC<sub>per-pre</sub> was most predictive for pCR (c-index = 0.79). Multivariable logistic regression analyses showed complementary value when combining DW-MRI and DCE-MRI for pCR prediction (c-index = 0.89).</p> <p>Both DW-MRI and DCE-MRI are promising in predicting response to nCRT in esophageal cancer. Combining both modalities provides complementary information, resulting in a higher predictive value.</p>