10.6084/m9.figshare.6293384.v1
Sophie E. Heethuis
Sophie E.
Heethuis
Lucas Goense
Lucas
Goense
Peter S. N. van Rossum
Peter S. N.
van Rossum
Alicia S. Borggreve
Alicia S.
Borggreve
Stella Mook
Stella
Mook
Francine E. M. Voncken
Francine E. M.
Voncken
Annemarieke Bartels-Rutten
Annemarieke
Bartels-Rutten
Berthe M. P. Aleman
Berthe M. P.
Aleman
Richard van Hillegersberg
Richard
van Hillegersberg
Jelle P. Ruurda
Jelle P.
Ruurda
Gert J. Meijer
Gert J.
Meijer
Jan J. W. Lagendijk
Jan J. W.
Lagendijk
Astrid L. H. M. W. van Lier
Astrid L. H. M. W.
van Lier
DW-MRI and DCE-MRI are of complementary value in predicting pathologic response to neoadjuvant chemoradiotherapy for esophageal cancer
Taylor & Francis Group
2018
five patients underwent
concentration time curve
49 %) patients
investigated .</ p
89 ).</ p
trg ≤ 2
predicting pathologic response
pre </ sub
predicting response
pre ),
potential benefit
p90 δauc
neoadjuvant chemoradiotherapy
good response
esophageal cancer
dynamic contrast
complementary value
79 ).
75th percentile
75 ).
2018-05-21 11:52:52
Dataset
https://tandf.figshare.com/articles/dataset/DW-MRI_and_DCE-MRI_are_of_complementary_value_in_predicting_pathologic_response_to_neoadjuvant_chemoradiotherapy_for_esophageal_cancer/6293384
<p>To explore the potential benefit and complementary value of a multiparametric approach using diffusion-weighted (DW-) and dynamic contrast-enhanced (DCE-) magnetic resonance imaging (MRI) for prediction of response to neoadjuvant chemoradiotherapy (nCRT) in esophageal cancer.</p> <p>Forty-five patients underwent both DW-MRI and DCE-MRI prior to nCRT (pre), during nCRT (week 2–3) (per) and after completion of nCRT, but prior to esophagectomy (post). Subsequently, histopathologic tumor regression grade (TRG) was assessed. Tumor apparent diffusion coefficient (ADC) and area-under-the-concentration time curve (AUC) were calculated for DW-MRI and DCE-MRI, respectively. The ability of these parameters to predict pathologic complete response (pCR, TRG1) or good response (GR, TRG ≤ 2) to nCRT was assessed. Furthermore the complementary value of DW-MRI and DCE-MRI was investigated.</p> <p>GR was found in 22 (49%) patients, of which 10 (22%) patients showed pCR. For DW-MRI, the 75th percentile (P75) ΔADC<sub>post-pre</sub> was most predictive for GR (c-index = 0.75). For DCE-MRI, P90 ΔAUC<sub>per-pre</sub> was most predictive for pCR (c-index = 0.79). Multivariable logistic regression analyses showed complementary value when combining DW-MRI and DCE-MRI for pCR prediction (c-index = 0.89).</p> <p>Both DW-MRI and DCE-MRI are promising in predicting response to nCRT in esophageal cancer. Combining both modalities provides complementary information, resulting in a higher predictive value.</p>