Aviram, Amir Shtaif, Biana Gat-Yablonski, Galia Yogev, Yariv The association between adipocytokines and glycemic control in women with gestational diabetes mellitus <p><b>Objective:</b> To evaluate the relationship between adipocytokines and glycemic control.</p> <p><b>Study design:</b> Prospective observational trial of gestations with gestational diabetes mellitus (GDM). Fasting glucose (FG), insulin, adiponectin, leptin, chemerin, retinol-binding protein 4 (RBP-4), osteocalcin, and resistin were measured. HomeOstasis model assessment of insulin resistance (HOMA-IR) and QUantitative insulin sensitivity ChecK Index (QUICKI) were calculated. Women who required medications for glycemic control were compared to women using nutritional therapy only.</p> <p><b>Results:</b> Overall, 75 women were included −26 (34.7%) required medications to achieve good glycemic control. Factors associated with poor control are as follows: low resistin (aOR 0.84), HOMA-IR (aOR 1.96), QUICKI (aOR 0.62), first trimester FG (aOR 1.43), and maternal age (aOR 1.26). HOMA-IR and QUICKI performed highest for prediction. Resistin, first trimester FG, maternal age, and QUICKI had an AUC of 0.878, sensitivity and specificity of 87.5% for the prediction of the need for medications.</p> <p><b>Conclusions:</b> Low resistin is associated with poor control. A model utilizing maternal age, first trimester fasting glucose, and first visit QUICKI yields good predictability.</p> Adipocytokines;gestational diabetes mellitus;glycemic control;therapy intervention 2018-07-23
    https://tandf.figshare.com/articles/dataset/The_association_between_adipocytokines_and_glycemic_control_in_women_with_gestational_diabetes_mellitus/6849641
10.6084/m9.figshare.6849641.v1