%0 Journal Article %A Ito, Shinsaku %A Yamamoto, Yuta %A Nishikawa, Toshio %D 2018 %T A concise synthesis of peramine, a metabolite of endophytic fungi %U https://tandf.figshare.com/articles/journal_contribution/A_concise_synthesis_of_peramine_a_metabolite_of_endophytic_fungi/7071728 %R 10.6084/m9.figshare.7071728.v1 %2 https://tandf.figshare.com/ndownloader/files/13000883 %K Peramine %K pyrrolopyrazinone %K guanidine %K one-pot reaction %K N-propargylation %X

The total synthesis of peramine, a natural product isolated from an endophytic fungi, has been achieved in four steps and 34% overall yield from known compounds. The key step was the one-pot construction of the pyrrolopyrazinone ring from pyrrole amide and propargyl bromide. The preparation of peramine-d4 as an internal standard for quantitative analysis by MS is also described.

Peramine, a natural product isolated from an endophytic fungi, was synthesized in four steps by one-pot construction of the pyrrolopyrazinone ring as a key step.

%I Taylor & Francis