10.6084/m9.figshare.7178834.v1 Mohamed H. Hekal Mohamed H. Hekal Fatma S. M. Abu El-Azm Fatma S. M. Abu El-Azm New potential antitumor quinazolinones derived from dynamic 2-undecyl benzoxazinone: Synthesis and cytotoxic evaluation Taylor & Francis Group 2018 Cytotoxic evaluation lauroyl chloride quinazolinone triazolo[4,3-a]quinoline-4-carbonitrile 2018-10-08 16:12:58 Journal contribution https://tandf.figshare.com/articles/journal_contribution/New_potential_antitumor_quinazolinones_derived_from_dynamic_2-undecyl_benzoxazinone_Synthesis_and_cytotoxic_evaluation/7178834 <p>Since the quinazoline and its derivatives have been considered as a novel class of cancer chemotherapeutic agents that show promising activity against different tumors, a new series of 6-iodo-2-undecylquinazolin-4(3<i>H</i>)-ones were prepared via reaction of 6-iodo-2-undecyl-4<i>H</i>-benzoxazin-4-one with nitrogen nucleophiles, namely, primary amines, 4-amino antipyrine, hydrazine hydrate, diamines, ethanol amine, and/or hydrazide derivatives and screened for their antitumor activity <i>in vitro</i> against a panel of three human tumor cell lines namely; hepatocellular carcinoma (liver) HepG2, colon cancer HCT-116, and mammary gland breast MCF-7. Compounds <b>14</b>, <b>16,</b> and <b>18</b> showed remarkable broad spectrum antitumor activity. All compounds were fully characterized by means of IR, MS, and <sup>1</sup>H-NMR spectra.</p>