10.6084/m9.figshare.7178837.v1
Ankita Singh
Ankita
Singh
Devla Bimal
Devla
Bimal
Rajesh Kumar
Rajesh
Kumar
Vipin K. Maikhuri
Vipin K.
Maikhuri
M. Thirumal
M.
Thirumal
Nihar Nalini Senapati
Nihar Nalini
Senapati
Ashok K. Prasad
Ashok K.
Prasad
Synthesis and antitubercular activity evaluation of 4-furano-coumarins and 3-furano-chromones
Taylor & Francis Group
2018
3-Furano-chromone
4-furano-coumarin
antitubercular activity
C–H/C–H functionalization
2018-10-08 16:12:59
Journal contribution
https://tandf.figshare.com/articles/journal_contribution/Synthesis_and_antitubercular_activity_evaluation_of_4-furano-coumarins_and_3-furano-chromones/7178837
<p>The synthesis of novel 4-furano-coumarins and 3-furano-chromones has been achieved using silver-mediated oxidative C–H/C–H functionalization of 4-ethynylcoumarin/3-ethynylchromone with ethyl acetoacetate in 80%–90% and 82%–90% yields, respectively. The structure of the synthesized compounds was established on the basis of their spectral data analysis and the structure of one of the 4-furano-coumarins has been further confirmed on the basis of its X-ray crystallographic study. All eight synthesized 4-furano-coumarins and 3-furano-chromones exhibited moderate antitubercular activity against sensitive reference strain H37Rv of <i>Mycobacterium tuberculosis.</i></p>