10.6084/m9.figshare.7178837.v1 Ankita Singh Ankita Singh Devla Bimal Devla Bimal Rajesh Kumar Rajesh Kumar Vipin K. Maikhuri Vipin K. Maikhuri M. Thirumal M. Thirumal Nihar Nalini Senapati Nihar Nalini Senapati Ashok K. Prasad Ashok K. Prasad Synthesis and antitubercular activity evaluation of 4-furano-coumarins and 3-furano-chromones Taylor & Francis Group 2018 3-Furano-chromone 4-furano-coumarin antitubercular activity C–H/C–H functionalization 2018-10-08 16:12:59 Journal contribution https://tandf.figshare.com/articles/journal_contribution/Synthesis_and_antitubercular_activity_evaluation_of_4-furano-coumarins_and_3-furano-chromones/7178837 <p>The synthesis of novel 4-furano-coumarins and 3-furano-chromones has been achieved using silver-mediated oxidative C–H/C–H functionalization of 4-ethynylcoumarin/3-ethynylchromone with ethyl acetoacetate in 80%–90% and 82%–90% yields, respectively. The structure of the synthesized compounds was established on the basis of their spectral data analysis and the structure of one of the 4-furano-coumarins has been further confirmed on the basis of its X-ray crystallographic study. All eight synthesized 4-furano-coumarins and 3-furano-chromones exhibited moderate antitubercular activity against sensitive reference strain H37Rv of <i>Mycobacterium tuberculosis.</i></p>