Piptolinic acids F–J, five new lanostane-type triterpenoids from <i>Piptoporus betulinus</i>
Qosimjon Khalilov
Liya Li
Yushuang Liu
Zeynep Tohtahon
Xiaoyu Chen
Haji Akber Aisa
Tao Yuan
10.6084/m9.figshare.7258028.v2
https://tandf.figshare.com/articles/journal_contribution/Piptolinic_acids_F_J_five_new_lanostane-type_triterpenoids_from_i_Piptoporus_betulinus_i_/7258028
<p>Five new lanostane-type triterpenoids, named piptolinic acids F − J (<b>1</b>–<b>5</b>), as well as seven known analogues (<b>6</b>–<b>12</b>), were isolated from methanolic extract of the fruiting bodies of <i>Piptoporus betulinus</i>. Compounds <b>1</b>–<b>4</b> were 24-methyl-lanostane triterpenoids, while compound <b>5</b> was a 3,4-<i>seco</i>-lanostane derivative. Their structures were established on the basis of extensive spectroscopic analysis (1D, 2D NMR, and HRESIMS). Cytotoxicity evaluation indicated that compound <b>6</b> exhibited moderate cytotoxic activity against human melanoma cell line A-375 (IC<sub>50</sub> = 42.8 μM) and human renal carcinoma cell line 786-O (IC<sub>50</sub> = 56.5 μM).</p>
2019-08-27 08:08:28
Piptoporus betulinus
polyporaceae
lanostane triterpenoid
cytotoxicity
A-375
786-O