An efficient heterogeneous gold(I)-catalyzed hydration of haloalkynes leading to α-halomethyl ketones
Sifan Hu
Dayi Liu
Chenyu Yan
Mingzhong Cai
10.6084/m9.figshare.7314578.v1
https://tandf.figshare.com/articles/journal_contribution/An_efficient_heterogeneous_gold_I_-catalyzed_hydration_of_haloalkynes_leading_to_-halomethyl_ketones/7314578
<p>A highly efficient heterogeneous gold(I)-catalyzed hydration of haloalkynes has been developed that proceeds smoothly under mild and neutral conditions and provides a general and practical route for the synthesis of a variety of α-halomethyl ketones with high atom-economy, excellent yield, and recyclability of the gold(I) catalyst. The presented method delivers an attractive alternative to classical α-halogenation of ketones.</p>
2018-11-08 10:56:03
Gold
hydration
haloalkyne
MCM-41
heterogeneous catalysis