Preventive and therapeutic effects of pigment and polysaccharides in <i>Lycium barbarum</i> on alcohol-induced fatty liver disease in mice
Dan Li
Lijun Sun
Yongli Yang
Zichao Wang
Xi Yang
Yurong Guo
10.6084/m9.figshare.7334726.v1
https://tandf.figshare.com/articles/journal_contribution/Preventive_and_therapeutic_effects_of_pigment_and_polysaccharides_in_i_Lycium_barbarum_i_on_alcohol-induced_fatty_liver_disease_in_mice/7334726
<p>This study aims to explore the preventive and therapeutic effects of <i>Lycium barbarum</i> pigment (LP) and polysaccharides (LBPs) on alcohol-induced fatty liver disease (AFLD) in mice, through the measurement of serum and hepatic biochemical indexes, morphologic pathological observation and expression of metabolism-related genes. The results showed that LP and LBPs were non-toxic. The body weight, liver index, and lipid metabolic indexes were significantly inhibited by LP and LBPs. Besides, LP and LBPs could protect liver from oxidative injury and allergy, as suggested by increased glutathione peroxidase (GSH-Px) and superoxide dismutase (SOD), reduced malondialdehyde (MDA) and inflammatory cytokine (TNF-α, IL-1β, IL-6). Furthermore, through RT-PCR, LP, and LBPs were found to regulate liver injury related metabolism by increasing expression of AMPK<sub>α2</sub> mRNA and reducing expressions of SREBP-1c, CYP2E1, TLR4, and Myd88 mRNA. Therefore, <i>Lycium barbarum</i> may be developed as a potential functional food regarding preventing and treating AFLD.</p>
2018-11-13 15:03:56
Lycium barbarum
pigment
polysaccharides
alcohol-induced fatty liver
metabolism indexes
mRNA expression
pigmento
polisacáridos
hígado graso inducido por el alcohol
índices metabólicos
expresión de mRNA