10.6084/m9.figshare.7418396.v1 Miroslav Novakovic Miroslav Novakovic Iris Djordjevic Iris Djordjevic Nina Todorovic Nina Todorovic Snezana Trifunovic Snezana Trifunovic Boban Andjelkovic Boban Andjelkovic Boris Mandic Boris Mandic Milka Jadranin Milka Jadranin Ivan Vuckovic Ivan Vuckovic Vlatka Vajs Vlatka Vajs Slobodan Milosavljevic Slobodan Milosavljevic Vele Tesevic Vele Tesevic New aurone epoxide and auronolignan from the heartwood of <i>Cotinus coggygria</i> Scop Taylor & Francis Group 2018 Cotinus coggygria Scop flavonoids cotinignan A semipreparative HPLC NMR 2018-12-04 23:00:49 Journal contribution https://tandf.figshare.com/articles/journal_contribution/New_aurone_epoxide_and_auronolignan_from_the_heartwood_of_i_Cotinus_coggygria_i_Scop/7418396 <p>New aurone epoxide, 2,10-oxy-10-methoxysulfuretin (<b>14</b>), and new auronolignan (<b>15</b>), named cotinignan A, were isolated by silica gel column and semipreparative HPLC chromatography from the methylene chloride/methanol extract of <i>Cotinus coggygria</i> Scop. heartwood. In addition, thirteen known secondary metabolites namely sulfuretin, 2,3-<i>trans</i>-fustin, fisetin, butin, butein, taxifolin, eriodictyol, 3',5,5',7–tetrahydroxyflavanone, 3',4',7-trihydroxyflavone, 3-<i>O</i>-methyl-2,3-<i>trans</i>-fustin, 3-<i>O</i>-galloyl-2,3-<i>trans</i>-fustin, <i>β</i>-resorcylic acid and 3-<i>O</i>-<i>β</i>-sitosterol glucoside were isolated as well. Their structures were elucidated by 1D and 2D NMR, HR-ESI-MS, IR and UV. Ten out of eleven isolated flavonoids possess 7, 3' and 4' hydroxy groups. These structural features could be considered as chemotaxonomic characteristic of flavonoids from <i>C. coggygria</i>. Cotinignan A (<b>15</b>) represents new subclass of secondary metabolites - auronolignans.</p> <p></p>