10.6084/m9.figshare.7454081.v1 Adil Omar Adil Omar Keyume Ablajan Keyume Ablajan Efficient one-pot catalyst-free synthesis of novel coumarin- spiro[indoline-3,4'-pyran] conjugates via three-component domino reaction in aqueous medium Taylor & Francis Group 2018 Coumarins spiro-indoline pyran one-pot synthesis catalyst-free 2018-12-12 06:44:13 Journal contribution https://tandf.figshare.com/articles/journal_contribution/Efficient_one-pot_catalyst-free_synthesis_of_novel_coumarin-_spiro_indoline-3_4_-pyran_conjugates_via_three-component_domino_reaction_in_aqueous_medium/7454081 <p>A simple, efficient, eco-friendly and catalyst-free procedure was developed for the construction of novel coumarin-spiro[indoline-3,4'-pyran] conjugates via three-component reactions of various synthetic beta-ketoesters with isatins and malononitrile in aqueous medium. In addition to operational simplicity and absence of tedious separation procedures, being catalyst–free is the prominent advantage of this method.</p>