%0 Journal Article %A Omar, Adil %A Ablajan, Keyume %D 2018 %T Efficient one-pot catalyst-free synthesis of novel coumarin- spiro[indoline-3,4'-pyran] conjugates via three-component domino reaction in aqueous medium %U https://tandf.figshare.com/articles/journal_contribution/Efficient_one-pot_catalyst-free_synthesis_of_novel_coumarin-_spiro_indoline-3_4_-pyran_conjugates_via_three-component_domino_reaction_in_aqueous_medium/7454081 %R 10.6084/m9.figshare.7454081.v1 %2 https://tandf.figshare.com/ndownloader/files/13803524 %K Coumarins %K spiro-indoline %K pyran %K one-pot synthesis %K catalyst-free %X

A simple, efficient, eco-friendly and catalyst-free procedure was developed for the construction of novel coumarin-spiro[indoline-3,4'-pyran] conjugates via three-component reactions of various synthetic beta-ketoesters with isatins and malononitrile in aqueous medium. In addition to operational simplicity and absence of tedious separation procedures, being catalyst–free is the prominent advantage of this method.

%I Taylor & Francis