10.6084/m9.figshare.7491911.v1
Abigail R. Smith
Abigail R.
Smith
Nathan P. Goodrich
Nathan P.
Goodrich
Charlotte A. Beil
Charlotte A.
Beil
Qian Liu
Qian
Liu
Robert M. Merion
Robert M.
Merion
Brenda W. Gillespie
Brenda W.
Gillespie
Jarcy Zee
Jarcy
Zee
Graphical representation of survival curves in the presence of time-dependent categorical covariates with application to liver transplantation
Taylor & Francis Group
2018
Cox regression
graphing
survival curves
time-dependent covariate
time-dependent interaction
2018-12-20 14:32:03
Dataset
https://tandf.figshare.com/articles/dataset/Graphical_representation_of_survival_curves_in_the_presence_of_time-dependent_categorical_covariates_with_application_to_liver_transplantation/7491911
<p>Graphical representation of survival curves is often used to illustrate associations between exposures and time-to-event outcomes. However, when exposures are time-dependent, calculation of survival probabilities is not straightforward. Our aim was to develop a method to estimate time-dependent survival probabilities and represent them graphically. Cox models with time-dependent indicators to represent state changes were fitted, and survival probabilities were plotted using pre-specified times of state changes. Time-varying hazard ratios for the state change were also explored. The method was applied to data from the Adult-to-Adult Living Donor Liver Transplantation Cohort Study (A2ALL). Survival curves showing a ‘split’ at a pre-specified time <i>t</i> allow for the qualitative comparison of survival probabilities between patients with similar baseline covariates who do and do not experience a state change at time <i>t</i>. Time since state change interactions can be visually represented to reflect changing hazard ratios over time. A2ALL study results showed differences in survival probabilities among those who did not receive a transplant, received a living donor transplant, and received a deceased donor transplant. These graphical representations of survival curves with time-dependent indicators improve upon previous methods and allow for clinically meaningful interpretation.</p>