Hu, Ji-Hong Zheng, Hong-Jie Facile synthesis of 2-nitromethyl aromatic ketones by insertion of benzynes into the C-C bond of α-nitroketones <p>A facile method to synthesize 2-nitromethyl aromatic ketones was developed. In the method, benzyne was generated in situ for the insertion to α-Nitroketones in one pot to achieve 2-nitromethyl aromatic ketones under mild conditions. Aromatic and aliphatic α-nitroketones were applied in the reaction, and the results show that aliphatic α-nitroketones gave excellent yields (up to 96%), while aromatic α-nitroketones gave moderate yields. The synthesized 2-nitromethyl aromatic ketones could be potential substrates to synthesize isoindoles.</p> 2-Nitromethyl aromatic ketone;α-nitroketone;benzyne;inserion 2019-01-18
    https://tandf.figshare.com/articles/journal_contribution/Facile_synthesis_of_2-nitromethyl_aromatic_ketones_by_insertion_of_benzynes_into_the_C-C_bond_of_-nitroketones/7604627
10.6084/m9.figshare.7604627.v1