10.6084/m9.figshare.7629215.v1
Victor C. Kok
Victor
C. Kok
Han-Wei Zhang
Han-Wei
Zhang
Chin-Teng Lin
Chin-Teng
Lin
Shih-Chung Huang
Shih-Chung
Huang
Ming-Feng Wu
Ming-Feng
Wu
Positive association between hypertension and urinary bladder cancer: epidemiologic evidence involving 79,236 propensity score-matched individuals
Taylor & Francis Group
2019
Essential hypertension
population-based cohort study
propensity analysis
urinary bladder cancer
2019-01-25 13:34:50
Journal contribution
https://tandf.figshare.com/articles/journal_contribution/Positive_association_between_hypertension_and_urinary_bladder_cancer_epidemiologic_evidence_involving_79_236_propensity_score-matched_individuals/7629215
<p><b>Introduction:</b> We hypothesized that hypertensive patients harbor a higher risk of urinary bladder (UB) cancer.</p> <p><b>Material and methods:</b> We performed a population-based cohort study on adults using a National Health Insurance Research Database (NHIRD) dataset. Hypertension and comparison non-hypertensive (COMP) groups comprising 39,618 patients each were propensity score-matched by age, sex, index date, and medical comorbidities. The outcome was incident UB cancer validated using procedure codes. We constructed multivariable Cox models to derive adjusted hazard ratios (aHRs) and 95% confidence intervals (CIs). Cumulative incidence was compared using a log-rank test.</p> <p><b>Results:</b> During a total follow-up duration of 380,525 and 372,020 person-years in the hypertension and COMP groups, 248 and 186 patients developed UB cancer, respectively, representing a 32% increase in the risk (aHR, 1.32; 95% CI, 1.09–1.60). Hypertensive women harbored a significantly increased risk of UB cancer (aHR, 1.55; 95% CI, 1.12–2.13) compared with non-hypertensive women, whereas men with hypertension had a statistically non-significant increased risk (aHR, 1.22; 95% CI, 0.96–1.55). The sensitivity analysis demonstrated that the increased risk was sustained throughout different follow-up durations for the entire cohort; a statistical increase in the risk was also noted among hypertensive men.</p> <p><b>Conclusion:</b> This nationwide population-based propensity score-matched cohort study supports a positive association between hypertension and subsequent UB cancer development.</p>