Balwe, Sandip Gangadhar Lim, Kwon Taek Cho, Byung Gwon Tae Jeong, Yeon One-pot four-component domino reaction for the synthesis of bifunctionalized spiro[indazolo[3,2-<i>b</i>]quinazoline-7,3′-indoline hybrids: A green approach <p>An efficient tandem route to obtain novel spiro[indazolo[3,2-<i>b</i>]quinazoline-7,3′-indolines has been explored. The one-step domino reaction proceeds via <i>in situ</i> generation of the 1<i>H</i>-indazol-3-amines followed by its reaction with the cyclic 1,3-dicarbonyls and isatin derivatives to furnish complex <i>N</i>-fused spiro-polyheterocyclic frameworks. This protocol describes a valuable route to concisely and feasibly obtain spiro[indazolo[3,2-<i>b</i>]quinazoline-7,3′-indolines from isatin derivatives. The present protocol is particularly attractive because of the following features: group-assisted-purification (GAP) chemistry process, low-cost solvent, convenience of operation, excellent atom economy, and high yields.</p> Broad substrate scope;construct tetracyclic ring in one-pot GAP Chemistry;excellent atom-economy;spiro[indazolo[3,2-b]quinazoline-7,3′-indolines 2019-01-30
    https://tandf.figshare.com/articles/journal_contribution/One-pot_four-component_domino_reaction_for_the_synthesis_of_bifunctionalized_spiro_indazolo_3_2-_i_b_i_quinazoline-7_3_-indoline_hybrids_A_green_approach/7648811
10.6084/m9.figshare.7648811.v1