%0 Journal Article %A Lin, Juo-Han %A Lee, Wen-Jui %A Wu, Han-Chung %A Wu, Chih-Hsiung %A Chen, Li-Ching %A Huang, Chi-Cheng %A Chang, Hang-Lung %A Cheng, Tzu-Chun %A Chang, Hui-Wen %A Ho, Chi-Tang %A Tu, Shih-Hsin %A Ho, Yuan-Soon %D 2019 %T Small G protein signalling modulator 2 (SGSM2) is involved in oestrogen receptor-positive breast cancer metastasis through enhancement of migratory cell adhesion via interaction with E-cadherin %U https://tandf.figshare.com/articles/journal_contribution/Small_G_protein_signalling_modulator_2_SGSM2_is_involved_in_oestrogen_receptor-positive_breast_cancer_metastasis_through_enhancement_of_migratory_cell_adhesion_via_interaction_with_E-cadherin/7706315 %R 10.6084/m9.figshare.7706315.v1 %2 https://tandf.figshare.com/ndownloader/files/14339771 %K SGSM %K breast cancer %K cell adhesion %K E-cadherin %K oestrogen receptor %K EMT %X

The function of small G protein signalling modulators (SGSM1/2/3) in cancer remains unknown. Our findings demonstrated that SGSM2 is a plasma membrane protein that strongly interacted with E-cadherin/β-catenin. SGSM2 downregulation enhanced the phosphorylation of focal adhesion kinase (FAK; Y576/577), decreased the expression of epithelial markers such as E-cadherin, β-catenin, and Paxillin, and increased the expression of Snail and Twist-1, which reduced cell adhesion and promoted cancer cell migration. Oestrogen and fibronectin treatment was found to promote the colocalization of SGSM2 at the leading edge with phospho-FAK (Y397). The BioGRID database showed that SGSM2 potentially interacts with cytoskeleton remodelling and cell-cell junction proteins. These evidences suggest that SGSM2 plays a role in modulating cell adhesion and cytoskeleton dynamics during cancer migration.

%I Taylor & Francis