10.6084/m9.figshare.7717802.v1
Khadijah Zai
Khadijah
Zai
Narumi Ishihara
Narumi
Ishihara
Hiroyuki Oguchi
Hiroyuki
Oguchi
Masato Hirota
Masato
Hirota
Akihiro Kishimura
Akihiro
Kishimura
Takeshi Mori
Takeshi
Mori
Koji Hase
Koji
Hase
Yoshiki Katayama
Yoshiki
Katayama
Regulation of inflammatory response of macrophages and induction of regulatory T cells by using retinoic acid-loaded nanostructured lipid carrier
Taylor & Francis Group
2019
Retinoic acid
macrophages
regulatory T cells
inflammatory response
nanostructured lipid carrier
2019-02-14 06:53:26
Journal contribution
https://tandf.figshare.com/articles/journal_contribution/Regulation_of_inflammatory_response_of_macrophages_and_induction_of_regulatory_T_cells_by_using_retinoic_acid-loaded_nanostructured_lipid_carrier/7717802
<p>Immunomodulatory function of all-trans retinoic acid (ATRA) has been gathering much attention for the therapy of autoimmune diseases. ATRA is a chemically unstable molecule which requires proper formulation for targeted delivery. Here we examined nanostructured lipid carrier (NLC) for the formulation of ATRA. NLC is a representative nanoparticle formulation especially suited for oral delivery. We established the preparation procedures of ATRA-containing NLC (NLC-RA) which minimizes the degradation of ATRA during the preparation process. NLC-RA thus obtained was taken up by macrophages and induced anti-inflammatory response via suppressing NF-κB signaling as well as via enhancing the production of anti-inflammatory cytokines. Moreover, NLC-RA enhanced differentiation of naïve T cells to regulatory T cells in the co-culture system with dendritic cells. These results suggest that NLC-RA is a promising alternative therapy for the autoimmune diseases especially intestinal bowel disease.</p> <p></p>