%0 Journal Article %A Rabêlo, Waléria F. %A Echemendía, Radell %D 2019 %T Synthesis of novel 1,4 naphthoquinone-based molecules by an Ugi-type four-component reaction %U https://tandf.figshare.com/articles/journal_contribution/Synthesis_of_novel_1_4_naphthoquinone-based_molecules_by_an_Ugi-type_four-component_reaction/7744859 %R 10.6084/m9.figshare.7744859.v1 %2 https://tandf.figshare.com/ndownloader/files/14412077 %K Enols %K isocyanide chemistry %K multicomponent reactions %K quinones %X

In an attempt to further exploit multicomponent reactions in the field of 1,4 naphthoquinone-based compounds, we describe an Ugi-type multicomponent approach for the synthesis of novel 3-substituted 1,4 naphthoquinone molecules. The process relies on the execution of an enol-Ugi reaction between an enol-3-nitro-1,4 naphthoquinone with different secondary diamines and isocyanides. The novel methodology showed great chemical efficiency and versatility.

%I Taylor & Francis