10.6084/m9.figshare.7745720.v1
Aristide Mfifen Munvera
Aristide Mfifen
Munvera
Blandine Marlyse Wache Ouahouo
Blandine Marlyse Wache
Ouahouo
Pierre Mkounga
Pierre
Mkounga
Michelle Ines Kanko Mbekou
Michelle Ines Kanko
Mbekou
Shehla Nuzhat
Shehla
Nuzhat
Muhammad Iqbal Choudhary
Muhammad Iqbal
Choudhary
Augustin Ephrem Nkengfack
Augustin
Ephrem Nkengfack
Chemical constituents from leaves and trunk bark of <i>Rinorea oblongifolia</i> (Violaceae)
Taylor & Francis Group
2019
Rinorea oblongifolia
coruleoellagic acid
friedelane-type triterpene
antibacterial activity
2019-02-20 12:20:12
Journal contribution
https://tandf.figshare.com/articles/journal_contribution/Chemical_constituents_from_leaves_and_trunk_bark_of_i_Rinorea_oblongifolia_i_Violaceae_/7745720
<p>Two new coruleoellagic acid derivatives, 3,4′,5,5′,-tetramethylcoruleoellagic acid <b>(1)</b>; 3′,4,4′,5,5′-pentamethylcoruleoellagic acid <b>(2)</b> and a new friedelane-type triterpene derivative rinol <b>(5)</b>, were isolated from leaves and trunk bark of <i>Rinorea oblongifolia</i> (Violaceae) along with seven known compounds including 3,3′,4,4′,5′-pentamethylcoruleoellagic acid <b>(3)</b>, hexamethylcoruleoellagic acid <b>(4),</b> 28-hydroxyfriedelin <b>(6),</b> friedelin <b>(7),</b> friedelan-3-ol <b>(8),</b> scopoletin <b>(9)</b> and β-sitosterol-3-<i>O</i>-β-D-glucopyranoside <b>(10).</b> Their structures were elucidated by means of spectroscopic methods including IR, 1D and 2D NMR in conjunction with mass spectrometry. Crude extracts of leaves and trunk bark as well as compounds <b>1–4</b> were evaluated for their antibacterial activities against 7 pathogenic bacterial strains (<i>Streptococcus pneumoniae</i> ATCC49619, <i>Staphylococcus aureus</i> ATCC 43300, <i>Klepsiella pneumoniae</i> ATCC 700603, <i>Haemophilus influenza</i> ATCC 49247, <i>Escherichia coli</i> ATCC 25922, <i>Pseudomonas aeruginosa</i> HM601, <i>Staphylococcus aureus</i> BAA 977). Compound <b>(3)</b> displayed noteworthy activity against <i>Haemophilus influenza</i> with MIC value of 9.38 µg/mL.</p>