10.6084/m9.figshare.7745720.v1 Aristide Mfifen Munvera Aristide Mfifen Munvera Blandine Marlyse Wache Ouahouo Blandine Marlyse Wache Ouahouo Pierre Mkounga Pierre Mkounga Michelle Ines Kanko Mbekou Michelle Ines Kanko Mbekou Shehla Nuzhat Shehla Nuzhat Muhammad Iqbal Choudhary Muhammad Iqbal Choudhary Augustin Ephrem Nkengfack Augustin Ephrem Nkengfack Chemical constituents from leaves and trunk bark of <i>Rinorea oblongifolia</i> (Violaceae) Taylor & Francis Group 2019 Rinorea oblongifolia coruleoellagic acid friedelane-type triterpene antibacterial activity 2019-02-20 12:20:12 Journal contribution https://tandf.figshare.com/articles/journal_contribution/Chemical_constituents_from_leaves_and_trunk_bark_of_i_Rinorea_oblongifolia_i_Violaceae_/7745720 <p>Two new coruleoellagic acid derivatives, 3,4′,5,5′,-tetramethylcoruleoellagic acid <b>(1)</b>; 3′,4,4′,5,5′-pentamethylcoruleoellagic acid <b>(2)</b> and a new friedelane-type triterpene derivative rinol <b>(5)</b>, were isolated from leaves and trunk bark of <i>Rinorea oblongifolia</i> (Violaceae) along with seven known compounds including 3,3′,4,4′,5′-pentamethylcoruleoellagic acid <b>(3)</b>, hexamethylcoruleoellagic acid <b>(4),</b> 28-hydroxyfriedelin <b>(6),</b> friedelin <b>(7),</b> friedelan-3-ol <b>(8),</b> scopoletin <b>(9)</b> and β-sitosterol-3-<i>O</i>-β-D-glucopyranoside <b>(10).</b> Their structures were elucidated by means of spectroscopic methods including IR, 1D and 2D NMR in conjunction with mass spectrometry. Crude extracts of leaves and trunk bark as well as compounds <b>1–4</b> were evaluated for their antibacterial activities against 7 pathogenic bacterial strains (<i>Streptococcus pneumoniae</i> ATCC49619, <i>Staphylococcus aureus</i> ATCC 43300, <i>Klepsiella pneumoniae</i> ATCC 700603, <i>Haemophilus influenza</i> ATCC 49247, <i>Escherichia coli</i> ATCC 25922, <i>Pseudomonas aeruginosa</i> HM601, <i>Staphylococcus aureus</i> BAA 977). Compound <b>(3)</b> displayed noteworthy activity against <i>Haemophilus influenza</i> with MIC value of 9.38 µg/mL.</p>