10.6084/m9.figshare.7770878.v2
Xue-Qing Song
Xue-Qing
Song
Zhi-Gang Wang
Zhi-Gang
Wang
Yang Wang
Yang
Wang
Yu-Ying Huang
Yu-Ying
Huang
Yu-Xuan Sun
Yu-Xuan
Sun
Yan Ouyang
Yan
Ouyang
Cheng-Zhi Xie
Cheng-Zhi
Xie
Jing-Yuan Xu
Jing-Yuan
Xu
Syntheses, characterization, DNA/HSA binding ability and antitumor activities of a family of isostructural binuclear lanthanide complexes containing hydrazine Schiff base
Taylor & Francis Group
2019
Lanthanide-based anticancer agent
hydrazine
DNA interaction
HSA binding
A549 cell
2019-03-26 13:23:06
Journal contribution
https://tandf.figshare.com/articles/journal_contribution/Syntheses_characterization_DNA_HSA_binding_ability_and_antitumor_activities_of_a_family_of_isostructural_binuclear_lanthanide_complexes_containing_hydrazine_Schiff_base/7770878
<p>Three dinuclear lanthanide complexes, [Ln<sub>2</sub>(L)<sub>2</sub>(μ<sub>3</sub>-OAc)<sub>4</sub>(H<sub>2</sub>O)<sub>2</sub>]⋅2H<sub>2</sub>O (Ln = La (<b>1</b>), Eu (<b>2</b>) and Dy (<b>3</b>), HL = N’-(2-hydroxybenzylidene) nicotinohydrazide), have been synthesized and characterized by IR, elemental analysis and X-ray single-crystal diffraction. Crystallographic study revealed that the representative complex <b>1</b> displays a discrete dinuclear structure with a distorted tricapped trigonal prismatic geometry around La(III) ion. The interaction of complexes <b>1</b>–<b>3</b> with CT-DNA was investigated by absorption spectra, fluorescence quenching and viscosity, which reveals that the complexes bind to CT-DNA with a moderate intercalative mode. The complexes exhibited obvious DNA cleavage activities in the presence of H<sub>2</sub>O<sub>2</sub>. All complexes could bind to human serum albumin (HSA) with medium affinity through static mode; thus, HSA could effectively transport complexes. Furthermore, three complexes exhibited specific cytotoxicity to A549 cancer cells in micromole magnitude than other cancer cells tested and less toxicity than cisplatin for normal human cells HUVEC, in which massive cell apoptosis was induced by complexes through producing DNA damage and suppressing DNA synthesis.</p> <p>Communicated by Ramaswamy H. Sarma</p>