10.6084/m9.figshare.7770878.v2 Xue-Qing Song Xue-Qing Song Zhi-Gang Wang Zhi-Gang Wang Yang Wang Yang Wang Yu-Ying Huang Yu-Ying Huang Yu-Xuan Sun Yu-Xuan Sun Yan Ouyang Yan Ouyang Cheng-Zhi Xie Cheng-Zhi Xie Jing-Yuan Xu Jing-Yuan Xu Syntheses, characterization, DNA/HSA binding ability and antitumor activities of a family of isostructural binuclear lanthanide complexes containing hydrazine Schiff base Taylor & Francis Group 2019 Lanthanide-based anticancer agent hydrazine DNA interaction HSA binding A549 cell 2019-03-26 13:23:06 Journal contribution https://tandf.figshare.com/articles/journal_contribution/Syntheses_characterization_DNA_HSA_binding_ability_and_antitumor_activities_of_a_family_of_isostructural_binuclear_lanthanide_complexes_containing_hydrazine_Schiff_base/7770878 <p>Three dinuclear lanthanide complexes, [Ln<sub>2</sub>(L)<sub>2</sub>(μ<sub>3</sub>-OAc)<sub>4</sub>(H<sub>2</sub>O)<sub>2</sub>]⋅2H<sub>2</sub>O (Ln = La (<b>1</b>), Eu (<b>2</b>) and Dy (<b>3</b>), HL = N’-(2-hydroxybenzylidene) nicotinohydrazide), have been synthesized and characterized by IR, elemental analysis and X-ray single-crystal diffraction. Crystallographic study revealed that the representative complex <b>1</b> displays a discrete dinuclear structure with a distorted tricapped trigonal prismatic geometry around La(III) ion. The interaction of complexes <b>1</b>–<b>3</b> with CT-DNA was investigated by absorption spectra, fluorescence quenching and viscosity, which reveals that the complexes bind to CT-DNA with a moderate intercalative mode. The complexes exhibited obvious DNA cleavage activities in the presence of H<sub>2</sub>O<sub>2</sub>. All complexes could bind to human serum albumin (HSA) with medium affinity through static mode; thus, HSA could effectively transport complexes. Furthermore, three complexes exhibited specific cytotoxicity to A549 cancer cells in micromole magnitude than other cancer cells tested and less toxicity than cisplatin for normal human cells HUVEC, in which massive cell apoptosis was induced by complexes through producing DNA damage and suppressing DNA synthesis.</p> <p>Communicated by Ramaswamy H. Sarma</p>