Aspergilolide, a steroid lactone produced by an endophytic fungus <i>Aspergillus sp</i>. MBL1612 isolated from <i>Paeonia ostii</i> ZhangPei-Liang WangGang XuFeng-Qing LiuJin-Song WangJu-Tao ZhangRui LiuHai-Tao HuJiang-Miao WangGuo-Kai WuPei-Yun 2019 <p>A new steroid lactone aspergilolide (<b>1</b>), and nine known compounds helvolic acid (<b>2</b>), verruculogen (<b>3</b>), tryprostatin B (<b>4</b>), 13-oxofumitremorgin B (<b>5</b>), fumitremorgin C (<b>6</b>), demethoxy fumitremorgin C (<b>7</b>), terezine D (<b>8</b>), aszonalenin (<b>9</b>), 12, 13-dihydroxy-fumitremorgin C (<b>10</b>) from cultures of the endophytic fungus <i>Aspergillus sp</i>. MBL1612. Their chemical structures were determined by a series of extensive spectroscopic methods. All of the compounds were isolated from this genus for the first time. The cytotoxicity against five human cancer cell lines of new compound were detected.</p>