10.6084/m9.figshare.7806401.v1
Yang-Hua Tang
Yang-Hua
Tang
Ting-Ting Liang
Ting-Ting
Liang
Ting-Ting Fan
Ting-Ting
Fan
Lawrence Jordan Keen
Lawrence Jordan
Keen
Xiao-Dan Zhang
Xiao-Dan
Zhang
Lin Xu
Lin
Xu
Qi Zhao
Qi
Zhao
Rong Zeng
Rong
Zeng
Bing-Nan Han
Bing-Nan
Han
Neo-debromoaplysiatoxin C, with new structural rearrangement, derived from debromoaplysiatoxin
Taylor & Francis Group
2019
Neo-debromoaplysiatoxin C
debromoaplysiatoxin
newly discovered structural frame
Lyngbya sp
2019-03-05 21:48:02
Journal contribution
https://tandf.figshare.com/articles/journal_contribution/Neo-debromoaplysiatoxin_C_with_new_structural_rearrangement_derived_from_debromoaplysiatoxin/7806401
<p>Neo-debromoaplysiatoxin C (<b>1</b>), a new member of the aplysiatoxin family, was isolated from the marine cyanobacterium <i>Lyngbya</i> sp. The structure of <b>1</b> was elucidated based on spectroscopic data, and its stereochemistry was determined from NOESY spectrum and biosynthetic considerations. This new compound presents an intriguing 10-membered lactone ring skeleton derived from debromoaplysiatoxin by structural rearrangement, which is the first example in the aplysiatoxin family. Its biological properties were evaluated for cytotoxicity, PKCĪ“ activation and inhibitory effects on potassium channel.</p> <p></p>