10.6084/m9.figshare.7806401.v1 Yang-Hua Tang Yang-Hua Tang Ting-Ting Liang Ting-Ting Liang Ting-Ting Fan Ting-Ting Fan Lawrence Jordan Keen Lawrence Jordan Keen Xiao-Dan Zhang Xiao-Dan Zhang Lin Xu Lin Xu Qi Zhao Qi Zhao Rong Zeng Rong Zeng Bing-Nan Han Bing-Nan Han Neo-debromoaplysiatoxin C, with new structural rearrangement, derived from debromoaplysiatoxin Taylor & Francis Group 2019 Neo-debromoaplysiatoxin C debromoaplysiatoxin newly discovered structural frame Lyngbya sp 2019-03-05 21:48:02 Journal contribution https://tandf.figshare.com/articles/journal_contribution/Neo-debromoaplysiatoxin_C_with_new_structural_rearrangement_derived_from_debromoaplysiatoxin/7806401 <p>Neo-debromoaplysiatoxin C (<b>1</b>), a new member of the aplysiatoxin family, was isolated from the marine cyanobacterium <i>Lyngbya</i> sp. The structure of <b>1</b> was elucidated based on spectroscopic data, and its stereochemistry was determined from NOESY spectrum and biosynthetic considerations. This new compound presents an intriguing 10-membered lactone ring skeleton derived from debromoaplysiatoxin by structural rearrangement, which is the first example in the aplysiatoxin family. Its biological properties were evaluated for cytotoxicity, PKCĪ“ activation and inhibitory effects on potassium channel.</p> <p></p>