Tang, Yang-Hua Liang, Ting-Ting Fan, Ting-Ting Keen, Lawrence Jordan Zhang, Xiao-Dan Xu, Lin Zhao, Qi Zeng, Rong Han, Bing-Nan Neo-debromoaplysiatoxin C, with new structural rearrangement, derived from debromoaplysiatoxin <p>Neo-debromoaplysiatoxin C (<b>1</b>), a new member of the aplysiatoxin family, was isolated from the marine cyanobacterium <i>Lyngbya</i> sp. The structure of <b>1</b> was elucidated based on spectroscopic data, and its stereochemistry was determined from NOESY spectrum and biosynthetic considerations. This new compound presents an intriguing 10-membered lactone ring skeleton derived from debromoaplysiatoxin by structural rearrangement, which is the first example in the aplysiatoxin family. Its biological properties were evaluated for cytotoxicity, PKCĪ“ activation and inhibitory effects on potassium channel.</p> <p></p> Neo-debromoaplysiatoxin C;debromoaplysiatoxin;newly discovered structural frame;Lyngbya sp 2019-03-05
    https://tandf.figshare.com/articles/journal_contribution/Neo-debromoaplysiatoxin_C_with_new_structural_rearrangement_derived_from_debromoaplysiatoxin/7806401
10.6084/m9.figshare.7806401.v1