10.6084/m9.figshare.7851341.v1 Lan-Fang Sun Lan-Fang Sun Bing Zhang Bing Zhang Xue-Jiao Chen Xue-Jiao Chen Xiao-Yun Wang Xiao-Yun Wang Bo-Wen Zhang Bo-Wen Zhang Yang-Yang Ji Yang-Yang Ji Kun-Chao Wu Kun-Chao Wu Jin-Yu Wu Jin-Yu Wu Zi-Bing Jin Zi-Bing Jin Circular RNAs in human and vertebrate neural retinas Taylor & Francis Group 2019 circular RNA different vertebrate species retina circPDE4B sponge 2019-03-15 13:38:34 Dataset https://tandf.figshare.com/articles/dataset/Circular_RNAs_in_human_and_vertebrate_neural_retinas/7851341 <p>Circular RNAs (circRNAs) belong to an endogenous class of RNA molecules with both ends covalently linked in a circle. Although their expression pattern in mammalian brain has been well-studied, the characteristics and functions of circRNAs in retinas remain unknown. To reveal the whole expression profiles of circRNAs in neural retina, we investigated retinal RNAs of human, monkey, mouse, pig, zebrafish and tree shrew and detected thousands of circRNAs showing conservation and variation in the retinas across different vertebrate species. We further investigated one of the abundant circRNAs, circPDE4B, identified in human retina. Silencing of circPDE4B significantly inhibited proliferation of human A549 cells. Functional assays demonstrated that circPDE4B could sponge miR-181C, thereby altering the cell phenotype. We have explored the retinal circRNA repertoires across human and different vertebrates, which provide new insights into the important role of circRNAs in the vertebrate retinas, as well as in related human diseases.</p>