10.6084/m9.figshare.7851341.v1
Lan-Fang Sun
Lan-Fang
Sun
Bing Zhang
Bing
Zhang
Xue-Jiao Chen
Xue-Jiao
Chen
Xiao-Yun Wang
Xiao-Yun
Wang
Bo-Wen Zhang
Bo-Wen
Zhang
Yang-Yang Ji
Yang-Yang
Ji
Kun-Chao Wu
Kun-Chao
Wu
Jin-Yu Wu
Jin-Yu
Wu
Zi-Bing Jin
Zi-Bing
Jin
Circular RNAs in human and vertebrate neural retinas
Taylor & Francis Group
2019
circular RNA
different vertebrate species
retina
circPDE4B
sponge
2019-03-15 13:38:34
Dataset
https://tandf.figshare.com/articles/dataset/Circular_RNAs_in_human_and_vertebrate_neural_retinas/7851341
<p>Circular RNAs (circRNAs) belong to an endogenous class of RNA molecules with both ends covalently linked in a circle. Although their expression pattern in mammalian brain has been well-studied, the characteristics and functions of circRNAs in retinas remain unknown. To reveal the whole expression profiles of circRNAs in neural retina, we investigated retinal RNAs of human, monkey, mouse, pig, zebrafish and tree shrew and detected thousands of circRNAs showing conservation and variation in the retinas across different vertebrate species. We further investigated one of the abundant circRNAs, circPDE4B, identified in human retina. Silencing of circPDE4B significantly inhibited proliferation of human A549 cells. Functional assays demonstrated that circPDE4B could sponge miR-181C, thereby altering the cell phenotype. We have explored the retinal circRNA repertoires across human and different vertebrates, which provide new insights into the important role of circRNAs in the vertebrate retinas, as well as in related human diseases.</p>