10.6084/m9.figshare.7873772.v1 Chunhua Deng Chunhua Deng Zhichao Zhang Zhichao Zhang Hongjun Li Hongjun Li Peng Bai Peng Bai Xian Cao Xian Cao Adrian Sandra Dobs Adrian Sandra Dobs Analysis of cardiovascular risk factors associated with serum testosterone levels according to the US 2011–2012 National Health and Nutrition Examination Survey Taylor & Francis Group 2019 NHANES testosterone deficiency cardiovascular disease BMI HDL-c CHD 2019-03-21 12:39:43 Journal contribution https://tandf.figshare.com/articles/journal_contribution/Analysis_of_cardiovascular_risk_factors_associated_with_serum_testosterone_levels_according_to_the_US_2011_2012_National_Health_and_Nutrition_Examination_Survey/7873772 <p><b>Objective:</b> To investigate associations between cardiovascular disease risk factors, including fasting glucose, cholesterol, high density lipoprotein cholesterol (HDL-c), LDL-c, blood pressure, body mass index (BMI), C-peptide, creatinine kinase, smoking, alcohol use, physical activity, C-reactive protein as well as homocysteine levels and cardiovascular events.</p> <p><b>Methods:</b> Data from 1545 men aged ≥40 years, with testosterone deficiency (TD) (<300 ng/dL) and non-TD (≥300 ng/dL) which were extracted from the National Health and Nutrition Examination Survey database 2011–2012 and analyzed.</p> <p><b>Results:</b> Multivariate logistic regression analysis showed positive associations between TD and BMI (≥35 vs. < 18.5: OR = 2.51, 95% CI: 1.19–5.32, <i>p</i> = .016), HDL-c (<0.91 vs. ≥0.91: OR = 1.60, 95% CI: 1.14–2.24, <i>p</i> = .006) and diabetes (diabetes vs. non-diabetes: OR = 1.48, 95% CI: 1.14–1.92, <i>p</i> = .004) as well as negative associations between TD and metabolic equivalent scores (≥12 vs. <12: OR = 0.69, 95% CI: 0.52–0.91, <i>p</i> = .009) and smoking (Ever vs. never: OR = 0.69, 95% CI: 0.51–0.94, <i>p</i> = .018). Furthermore, total serum testosterone levels were lower in patients with heart failure (<i>p</i> = .04) and angina/angina pectoris (<i>p</i> = .001) compared with subjects without these cardiac problems.</p> <p><b>Conclusion:</b> Low serum testosterone was associated with multiple risk factors for CHD.</p>