10.6084/m9.figshare.7873772.v1
Chunhua Deng
Chunhua
Deng
Zhichao Zhang
Zhichao
Zhang
Hongjun Li
Hongjun
Li
Peng Bai
Peng
Bai
Xian Cao
Xian
Cao
Adrian Sandra Dobs
Adrian Sandra
Dobs
Analysis of cardiovascular risk factors associated with serum testosterone levels according to the US 2011–2012 National Health and Nutrition Examination Survey
Taylor & Francis Group
2019
NHANES
testosterone deficiency
cardiovascular disease
BMI
HDL-c
CHD
2019-03-21 12:39:43
Journal contribution
https://tandf.figshare.com/articles/journal_contribution/Analysis_of_cardiovascular_risk_factors_associated_with_serum_testosterone_levels_according_to_the_US_2011_2012_National_Health_and_Nutrition_Examination_Survey/7873772
<p><b>Objective:</b> To investigate associations between cardiovascular disease risk factors, including fasting glucose, cholesterol, high density lipoprotein cholesterol (HDL-c), LDL-c, blood pressure, body mass index (BMI), C-peptide, creatinine kinase, smoking, alcohol use, physical activity, C-reactive protein as well as homocysteine levels and cardiovascular events.</p> <p><b>Methods:</b> Data from 1545 men aged ≥40 years, with testosterone deficiency (TD) (<300 ng/dL) and non-TD (≥300 ng/dL) which were extracted from the National Health and Nutrition Examination Survey database 2011–2012 and analyzed.</p> <p><b>Results:</b> Multivariate logistic regression analysis showed positive associations between TD and BMI (≥35 vs. < 18.5: OR = 2.51, 95% CI: 1.19–5.32, <i>p</i> = .016), HDL-c (<0.91 vs. ≥0.91: OR = 1.60, 95% CI: 1.14–2.24, <i>p</i> = .006) and diabetes (diabetes vs. non-diabetes: OR = 1.48, 95% CI: 1.14–1.92, <i>p</i> = .004) as well as negative associations between TD and metabolic equivalent scores (≥12 vs. <12: OR = 0.69, 95% CI: 0.52–0.91, <i>p</i> = .009) and smoking (Ever vs. never: OR = 0.69, 95% CI: 0.51–0.94, <i>p</i> = .018). Furthermore, total serum testosterone levels were lower in patients with heart failure (<i>p</i> = .04) and angina/angina pectoris (<i>p</i> = .001) compared with subjects without these cardiac problems.</p> <p><b>Conclusion:</b> Low serum testosterone was associated with multiple risk factors for CHD.</p>