10.6084/m9.figshare.7887863.v1
Giuseppina Sanna
Giuseppina
Sanna
Silvia Madeddu
Silvia
Madeddu
Alessandra Serra
Alessandra
Serra
David Collu
David
Collu
Thomas Efferth
Thomas
Efferth
F. Lukmanul Hakkim
F. Lukmanul
Hakkim
Luay Rashan
Luay
Rashan
Anti-poliovirus activity of <i>Nerium oleander</i> aqueous extract
Taylor & Francis Group
2019
Apocynaceae
Nerium oleander
hot extract
cold extract
poliovirus
antiviral activity
2019-03-25 17:19:38
Journal contribution
https://tandf.figshare.com/articles/journal_contribution/Anti-poliovirus_activity_of_i_Nerium_oleander_i_aqueous_extract/7887863
<p><i>Nerium oleander</i> (NO), a member of the Apocynaceae family, is an ornamental plant. In this study, we evaluated the antiviral activity of hot and cold extract of NO against six different viruses such as herpes simplex virus type 1 (HSV-1), polio virus type 1 (Sb-1), vesicular stomatitis virus (VSV), reovirus type-1 (Reo-1), human immunodeficiency virus type-1 (HIV-1), and yellow fever virus (YFV). Interestingly the results of plaque reduction assay demonstrated that both, hot extract and cold extract (breastin) of NO inhibited Sb-1 viral infection.</p> <p>In order to identify the mechanism by which NO exerts its antiviral activity, the virucidal effect, the time of addition and the adsorption assay were carried out. Results demonstrated that NO exerts its effect after infection period, particularly during the first two hours post infection.</p>