%0 Journal Article %A Prasad, Tangella Nagendra %A Eeda, Koti Reddy %A Gudise, Veera Babu %A Basha, Shaik Firoj %A Anwar, Shaik %D 2019 %T Design, synthesis and biological evaluation of substituted 2-amino-1,3-thiazine derivatives as antituberculosis and anti-cancer agents %U https://tandf.figshare.com/articles/journal_contribution/Design_synthesis_and_biological_evaluation_of_substituted_2-amino-1_3-thiazine_derivatives_as_antituberculosis_and_anti-cancer_agents/8003678 %R 10.6084/m9.figshare.8003678.v1 %2 https://tandf.figshare.com/ndownloader/files/14906531 %K 2-amino-,1,3-thiazine %K Mycobacterium tuberculosis H37Rv ATCC 27294 %K human breast cancer MCF-7 %K human esophageal cancer EC-9706 %K cytotoxic activity %K antituberculosis agent %K anticancer agent %X

A series of substituted 2-amino-1,3-thiazines were synthesized as amides (9a-9i), carbamates (9j-9m), sulfonamides (9n-9o) and urea derivatives (9p-9q) by treating the compound 7 with acid chlorides (8a-8i), chloroformates (8j-8m), sulfonyl chlorides (8n-8o) and isocyanates (8p-8q) respectively. The synthesized compounds (9a-9q) were screened for antituberculosis activity against Mycobacterium tuberculosis H37Rv ATCC 27294 and the results show that some of these derivatives possess good activity against Mycobacterium tuberculosis H37Rv ATCC 27294. A few also display promising cytotoxic activity against human breast cancer MCF-7 and human esophageal cancer EC-9706 cell lines. Regarding both biological profiles 9b, 9m and 9h are the most active for anti-cancer, anti-TB activity.

%I Taylor & Francis