10.6084/m9.figshare.8094008.v1 Travis F. Henchie Travis F. Henchie Ellen M. Gravallese Ellen M. Gravallese Todd L. Bredbenner Todd L. Bredbenner Karen L. Troy Karen L. Troy An image-based method to measure joint deformity in inflammatory arthritis: development and pilot study Taylor & Francis Group 2019 Coherent point drift HRpQCT CT imaging inflammatory arthritis MCP 2019-05-08 07:37:06 Journal contribution https://tandf.figshare.com/articles/journal_contribution/An_image-based_method_to_measure_joint_deformity_in_inflammatory_arthritis_development_and_pilot_study/8094008 <p>Quantifying joint deformity in people with rheumatoid (RA) and psoriatic arthritis (PsA) remains challenging. Here, we demonstrate a new method to measure bone erosions and abnormal periosteal growths, based on the difference between a predicted healthy and actual diseased joint surface. We optimized the method by creating and measuring artificial bone erosions and growths. Then we measured 46 healthy and diseased patient surfaces. We found average sensitivity errors of ≤0.27 mm when measuring artificial erosions and growths. Patients had significantly more bone erosion than healthy subjects. Surface based outcomes are a novel way to interpret and quantify bone changes in PsA and RA.</p>