10.6084/m9.figshare.8094008.v1
Travis F. Henchie
Travis F.
Henchie
Ellen M. Gravallese
Ellen M.
Gravallese
Todd L. Bredbenner
Todd L.
Bredbenner
Karen L. Troy
Karen L.
Troy
An image-based method to measure joint deformity in inflammatory arthritis: development and pilot study
Taylor & Francis Group
2019
Coherent point drift
HRpQCT
CT
imaging
inflammatory arthritis
MCP
2019-05-08 07:37:06
Journal contribution
https://tandf.figshare.com/articles/journal_contribution/An_image-based_method_to_measure_joint_deformity_in_inflammatory_arthritis_development_and_pilot_study/8094008
<p>Quantifying joint deformity in people with rheumatoid (RA) and psoriatic arthritis (PsA) remains challenging. Here, we demonstrate a new method to measure bone erosions and abnormal periosteal growths, based on the difference between a predicted healthy and actual diseased joint surface. We optimized the method by creating and measuring artificial bone erosions and growths. Then we measured 46 healthy and diseased patient surfaces. We found average sensitivity errors of ≤0.27 mm when measuring artificial erosions and growths. Patients had significantly more bone erosion than healthy subjects. Surface based outcomes are a novel way to interpret and quantify bone changes in PsA and RA.</p>