Modeling the effect of blood vessel bifurcation ratio on occlusive thrombus formation
Hari Hara Sudhan Lakshmanan
Joseph J. Shatzel
Sven R. Olson
Owen J.T. McCarty
Jeevan Maddala
10.6084/m9.figshare.8094167.v1
https://tandf.figshare.com/articles/journal_contribution/Modeling_the_effect_of_blood_vessel_bifurcation_ratio_on_occlusive_thrombus_formation/8094167
<p>Vascular geometry is a major determinant of the hemodynamics that promote or prevent unnecessary vessel occlusion from thrombus formation. Bifurcations in the vascular geometry are repeating structures that introduce flow separation between parent and daughter vessels. We modelled the blood flow and shear rate in a bifurcation during thrombus formation and show that blood vessel bifurcation ratios determine the maximum shear rate on the surface of a growing thrombus. We built an analytical model that may aid in predicting microvascular bifurcation ratios that are prone to occlusive thrombus formation. We also observed that bifurcation ratios that adhere to Murray’s law of bifurcations may be protected from occlusive thrombus formation. These results may be useful in the rational design of diagnostic microfluidic devices and microfluidic blood oxygenators.</p>
2019-05-08 09:09:29
Shear rate
microvasculature
occlusion
bifurcation
blood
hemodynamics