FW0622, a new siderophore isolated from marine <i>Verrucosispora</i> sp. by genomic mining Wei Zhao Fei Peng Chuan-xi Wang Yang Xie Ru Lin Zhi-kai Fang Fei Sun Yun-yang Lian Hong Jiang 10.6084/m9.figshare.8113133.v1 https://tandf.figshare.com/articles/journal_contribution/FW0622_a_new_siderophore_isolated_from_marine_i_Verrucosispora_i_sp_by_genomic_mining/8113133 <p>Using the draft genome sequence of <i>Verrucosispora</i> sp. FIM060022, we have identified a new desferrioxamine-like siderophore, FW0622. This is the first chemically characterized siderophore obtained from <i>Verrucosispora</i>. The structure was elucidated by extensive spectral analyses. The biosynthetic pathway of FW0622 was proposed to occur via the non-ribosomal peptide synthetase (NRPS)-independent (NIS) synthetase pathway based on the putative biosynthetic siderophore gene cluster in FIM060022. The results demonstrate that marine-derived <i>Verrucosispora</i> species deserve recognition as an important source of new natural products. Furthermore, this study verified that genome mining is an effective way to identify compounds that may be overlooked by traditional methods.</p> 2019-05-11 06:59:10 Genome mining siderophore biosynthesis pathway Verrucosispora