FW0622, a new siderophore isolated from marine <i>Verrucosispora</i> sp. by genomic mining
Wei Zhao
Fei Peng
Chuan-xi Wang
Yang Xie
Ru Lin
Zhi-kai Fang
Fei Sun
Yun-yang Lian
Hong Jiang
10.6084/m9.figshare.8113133.v1
https://tandf.figshare.com/articles/journal_contribution/FW0622_a_new_siderophore_isolated_from_marine_i_Verrucosispora_i_sp_by_genomic_mining/8113133
<p>Using the draft genome sequence of <i>Verrucosispora</i> sp. FIM060022, we have identified a new desferrioxamine-like siderophore, FW0622. This is the first chemically characterized siderophore obtained from <i>Verrucosispora</i>. The structure was elucidated by extensive spectral analyses. The biosynthetic pathway of FW0622 was proposed to occur via the non-ribosomal peptide synthetase (NRPS)-independent (NIS) synthetase pathway based on the putative biosynthetic siderophore gene cluster in FIM060022. The results demonstrate that marine-derived <i>Verrucosispora</i> species deserve recognition as an important source of new natural products. Furthermore, this study verified that genome mining is an effective way to identify compounds that may be overlooked by traditional methods.</p>
2019-05-11 06:59:10
Genome mining
siderophore
biosynthesis pathway
Verrucosispora