Iijima, Mutsumi Orimo, Satoshi Terashi, Hiroo Suzuki, Masahiko Hayashi, Akito Shimura, Hideki Mitoma, Hiroshi Kitagawa, Kazuo Okuma, Yasuyuki Efficacy of istradefylline for gait disorders with freezing of gait in Parkinson’s disease: A single-arm, open-label, prospective, multicenter study <p><b>Background</b>: Gait disorders are common in Parkinson’s disease patients who respond poorly to dopaminergic treatment. Blockade of adenosine A<sub>2A</sub> receptors is expected to improve gait disorders. Istradefylline is a first-in-class selective adenosine A<sub>2A</sub> receptor antagonist with benefits for motor complications associated with Parkinson’s disease.</p> <p><b>Research design and methods</b>: This multicenter, open-label, single-group, prospective interventional study evaluated changes in total gait-related scores of the Part II/III Movement Disorder Society-Unified Parkinson’s Disease Rating Scale (MDS-UPDRS) and Freezing of Gait Questionnaire (FOG-Q) in 31 Parkinson’s disease patients treated with istradefylline. Gait analysis by portable gait rhythmogram was performed.</p> <p><b>Results</b>: MDS-UPDRS Part III gait-related total scores significantly decreased at Weeks 4–12 from baseline with significant improvements in gait, freezing of gait, and postural stability. Significant decreases in MDS-UPDRS Part II total scores and individual item scores at Week 12 indicated improved daily living activities. At Week 12, there were significant improvements in FOG-Q, new FOG-Q, and overall movement per 48 h measured by portable gait rhythmogram. Adverse events occurred in 7/31 patients.</p> <p><b>Conclusions</b>: Istradefylline improved gait disorders in Parkinson’s disease patients complicated with freezing of gait, improving their quality of life. No unexpected adverse drug reactions were identified.</p> <p><b>Trial registration</b>: UMIN-CTR (UMIN000020288).</p> Adenosine A2A receptor antagonist;freezing of gait;gait disorders;istradefylline;Parkinson’s disease 2019-05-28
    https://tandf.figshare.com/articles/dataset/Efficacy_of_istradefylline_for_gait_disorders_with_freezing_of_gait_in_Parkinson_s_disease_A_single-arm_open-label_prospective_multicenter_study/8192378
10.6084/m9.figshare.8192378.v1