Durgadevi, Ravindran Ravi, Arumugam Veera Alexpandi, Rajaiah Swetha, Thirukannamangai Krishnan Abirami, Gurusamy Vishnu, Selvam Pandian, Shunmugaiah Karutha Virulence targeted inhibitory effect of linalool against the exclusive uropathogen <i>Proteus mirabilis</i> <p><i>Proteus mirabilis</i> is one of the leading causes of catheter-associated UTIs (CAUTI) in individuals with prolonged urinary catheterization. Since, biofilm assisted antibiotic resistance is reported to complicate the treatment strategies of <i>P. mirabilis</i> infections, the present study was aimed to attenuate biofilm and virulence factor production in <i>P. mirabilis.</i> Linalool is a naturally occurring monoterpene alcohol found in a wide range of flowers and spice plants and has many biological applications. In this study, linalool exhibited concentration dependent anti-biofilm activity against crystalline biofilm of <i>P. mirabilis</i> through reduced production of the virulence enzyme urease that raises the urinary pH and drives the formation of crystals (struvite) in the biofilm. The results of q-PCR analysis unveiled the down regulation of biofilm/virulence associated genes upon linalool treatment, which was in correspondence with the <i>in vitro</i> bioassays. Thus, this study reports the feasibility of linalool acting as a promising anti-biofilm agent against <i>P. mirabilis</i> mediated CAUTI.</p> Antibiofilm activity;antivirulence activity;crystalline biofilm;linalool;motility;proteus mirabilis 2019-05-30
    https://tandf.figshare.com/articles/dataset/Virulence_targeted_inhibitory_effect_of_linalool_against_the_exclusive_uropathogen_i_Proteus_mirabilis_i_/8204126
10.6084/m9.figshare.8204126.v1