10.6084/m9.figshare.8268542.v1
Xuan-Ming Zhang
Xuan-Ming
Zhang
Li-Wen Han
Li-Wen
Han
Wen-Long Sheng
Wen-Long
Sheng
Xiao-Bin Li
Xiao-Bin
Li
Shan-Shan Zhang
Shan-Shan
Zhang
Jing-Lan Guo
Jing-Lan
Guo
Hou-Wen Lin
Hou-Wen
Lin
Ke-Chun Liu
Ke-Chun
Liu
Two novel non-holostane type glycosides from the viscera of sea cucumber <i>Apostichopus japonicus</i>
Taylor & Francis Group
2019
Apostichopus japonicus
viscera
non-holostane
glycosides
structural identification
antitumor
2019-06-13 11:41:06
Journal contribution
https://tandf.figshare.com/articles/journal_contribution/Two_novel_non-holostane_type_glycosides_from_the_viscera_of_sea_cucumber_i_Apostichopus_japonicus_i_/8268542
<p>Two novel glycosides, apostichoposide A<sub>1</sub> (<b>1</b>) and B<sub>1</sub> (<b>2</b>), were isolated from the viscera of Chinese sea cucumbers (<i>Apostichopus japonicus</i>, Selenka) collected in the Bohai sea. Both the isolated glycosides were characterized by non-holostane type aglycones having 18(16)-lactone and 7(8)-double bond. Cytotoxic activities of the two compounds were evaluated against three human cancer cell lines. Compound <b>1</b> had adequate cytotoxic activity against MGC-803 and PC-3M cell lines. Our results indicated that glycosides present in <i>A. japonicus</i> viscera are an important high value resource for biotechnological applications.</p>