10.6084/m9.figshare.8268542.v1 Xuan-Ming Zhang Xuan-Ming Zhang Li-Wen Han Li-Wen Han Wen-Long Sheng Wen-Long Sheng Xiao-Bin Li Xiao-Bin Li Shan-Shan Zhang Shan-Shan Zhang Jing-Lan Guo Jing-Lan Guo Hou-Wen Lin Hou-Wen Lin Ke-Chun Liu Ke-Chun Liu Two novel non-holostane type glycosides from the viscera of sea cucumber <i>Apostichopus japonicus</i> Taylor & Francis Group 2019 Apostichopus japonicus viscera non-holostane glycosides structural identification antitumor 2019-06-13 11:41:06 Journal contribution https://tandf.figshare.com/articles/journal_contribution/Two_novel_non-holostane_type_glycosides_from_the_viscera_of_sea_cucumber_i_Apostichopus_japonicus_i_/8268542 <p>Two novel glycosides, apostichoposide A<sub>1</sub> (<b>1</b>) and B<sub>1</sub> (<b>2</b>), were isolated from the viscera of Chinese sea cucumbers (<i>Apostichopus japonicus</i>, Selenka) collected in the Bohai sea. Both the isolated glycosides were characterized by non-holostane type aglycones having 18(16)-lactone and 7(8)-double bond. Cytotoxic activities of the two compounds were evaluated against three human cancer cell lines. Compound <b>1</b> had adequate cytotoxic activity against MGC-803 and PC-3M cell lines. Our results indicated that glycosides present in <i>A. japonicus</i> viscera are an important high value resource for biotechnological applications.</p>