10.6084/m9.figshare.8313137.v1
Peng Li
Peng
Li
Shao-Xin Shen
Shao-Xin
Shen
Ling-Xue Liu
Ling-Xue
Liu
Jian-Hua Xu
Jian-Hua
Xu
Xin-Hua Ma
Xin-Hua
Ma
Dong-Mei Shi
Dong-Mei
Shi
Zhi-Qiang Zhang
Zhi-Qiang
Zhang
A new demethyl abietane diterpenoid from the roots of <i>Tripterygium wilfordii</i>
Taylor & Francis Group
2019
Tripterygium wilfordii
diterpenoids
triterpenes
cytotoxicity
2019-06-24 07:04:55
Journal contribution
https://tandf.figshare.com/articles/journal_contribution/A_new_demethyl_abietane_diterpenoid_from_the_roots_of_i_Tripterygium_wilfordii_i_/8313137
<p>A new demethyl abietane diterpenoid, Triptotin K (<b>3</b>) together with three known compounds, friedelin (<b>1</b>), canophyllal (<b>2</b>), and triptonoterpene (<b>4</b>) were isolated from the roots of <i>Tripterygium wilfordii</i> Hook. f. by silica gel column and preparative high performance liquid chromatography. Their structures were determined by extensive NMR data and mass spectroscopic analysis. Triptotin K showed cytotoxic activities against KB, KBv200, HepG2, and MCF-7/ADM cells lines with IC<sub>50</sub> values of 29.88, 36.50, 39.55, and 41.38 μM, respectively.</p>