10.6084/m9.figshare.8313137.v1 Peng Li Peng Li Shao-Xin Shen Shao-Xin Shen Ling-Xue Liu Ling-Xue Liu Jian-Hua Xu Jian-Hua Xu Xin-Hua Ma Xin-Hua Ma Dong-Mei Shi Dong-Mei Shi Zhi-Qiang Zhang Zhi-Qiang Zhang A new demethyl abietane diterpenoid from the roots of <i>Tripterygium wilfordii</i> Taylor & Francis Group 2019 Tripterygium wilfordii diterpenoids triterpenes cytotoxicity 2019-06-24 07:04:55 Journal contribution https://tandf.figshare.com/articles/journal_contribution/A_new_demethyl_abietane_diterpenoid_from_the_roots_of_i_Tripterygium_wilfordii_i_/8313137 <p>A new demethyl abietane diterpenoid, Triptotin K (<b>3</b>) together with three known compounds, friedelin (<b>1</b>), canophyllal (<b>2</b>), and triptonoterpene (<b>4</b>) were isolated from the roots of <i>Tripterygium wilfordii</i> Hook. f. by silica gel column and preparative high performance liquid chromatography. Their structures were determined by extensive NMR data and mass spectroscopic analysis. Triptotin K showed cytotoxic activities against KB, KBv200, HepG2, and MCF-7/ADM cells lines with IC<sub>50</sub> values of 29.88, 36.50, 39.55, and 41.38 μM, respectively.</p>