Hekal, Mohamed H. Abu El-Azm, Fatma S. M. Atta-Allah, Saad R. Ecofriendly and highly efficient microwave-induced synthesis of novel quinazolinone-undecyl hybrids with <i>in vitro</i> antitumor activity <p>Novel <i>N</i>-alkyl-quinazolin-4-one derivatives <b>3–5</b> were obtained from reaction of 6-Iodo-2-undecylquinazolin-4(3<i>H</i>)-one <b>(2)</b> with different alkyl halides. Hydrazinolysis of compound <b>5</b> gave the acetohydrazide <b>6</b> which reacted with different carbon electrophiles to produce 2-undecyl-4(3<i>H</i>)-quinazolinone derivatives. The new products were obtained by either conventional method or by microwave assisting technique and the structure of all products was confirmed by elemental and spectral data. The ecofriendly microwave provides an efficiency over than conventional method in many aspects. All the synthesized products were tested <i>in vitro</i> against a panel of three human tumor cell lines, namely, hepatocellular carcinoma (liver) HepG2, colon cancer HCT-116, and mammary gland breast MCF-7. Almost all of the tested compounds showed satisfactory activity.</p> Quinazolinone;1,3-dioxoisoindoline;isoquinolin-1,3-dione;antitumor activity;microwave irradiation;benzoxazinone 2019-08-13
    https://tandf.figshare.com/articles/journal_contribution/Ecofriendly_and_highly_efficient_microwave-induced_synthesis_of_novel_quinazolinone-undecyl_hybrids_with_i_in_vitro_i_antitumor_activity/8845136
10.6084/m9.figshare.8845136.v2