10.6084/m9.figshare.8851424.v2
Shengnan Tang
Shengnan
Tang
Aiping Wang
Aiping
Wang
Xiuju Yan
Xiuju
Yan
Liuxiang Chu
Liuxiang
Chu
Xiucheng Yang
Xiucheng
Yang
Yina Song
Yina
Song
Kaoxiang Sun
Kaoxiang
Sun
Xin Yu
Xin
Yu
Rongxia Liu
Rongxia
Liu
Zimei Wu
Zimei
Wu
Peng Xue
Peng
Xue
Brain-targeted intranasal delivery of dopamine with borneol and lactoferrin co-modified nanoparticles for treating Parkinson’s disease
Taylor & Francis Group
2020
Dopamine
lactoferrin
borneol
nose-to-brain targeted nanoparticles
Parkinson’s disease
2020-01-13 16:03:22
Journal contribution
https://tandf.figshare.com/articles/journal_contribution/Brain-targeted_intranasal_delivery_of_dopamine_with_borneol_and_lactoferrin_co-modified_nanoparticles_for_treating_Parkinson_s_disease/8851424
<p>Efficient delivery of brain-targeted drugs is highly important for successful therapy in Parkinson’s disease (PD). This study was designed to formulate borneol and lactoferrin co-modified nanoparticles (Lf-BNPs) encapsulated dopamine as a novel drug delivery system to achieve maximum therapeutic efficacy and reduce side effects for PD. Dopamine Lf-BNPs were prepared using the double emulsion solvent evaporation method and evaluated for physicochemical and pharmaceutical properties. <i>In vitro</i> cytotoxicity studies indicated that treatment with dopamine Lf-BNPs has relatively low cytotoxicity in SH-SY5Y and 16HBE cells. Qualitative and quantitative cellular uptake experiments indicated that Lf modification of NPs increased cellular uptake of SH-SY5Y cells and 16HBE cells, and borneol modification can promote the cellular uptake of 16HBE. <i>In vivo</i> pharmacokinetic studies indicated that AUC<sub>0–12 h</sub> in the rat brain for dopamine Lf-BNPs was significantly higher (<i>p</i> < .05) than that of dopamine nanoparticles. Intranasal administration of dopamine Lf-BNPs effectively alleviated the 6-hydroxydopamine-induced striatum lesion in rats as indicated by the contralateral rotation behavior test and results for striatal monoamine neurotransmitter content detection. Taken together, intranasal administration of dopamine Lf-BNPs may be an effective drug delivery system for Parkinson’s disease.</p>