10.6084/m9.figshare.9205199.v1 Yingjie Zhang Yingjie Zhang Huiling Wang Huiling Wang Xuedong Jia Xuedong Jia Shuzhang Du Shuzhang Du Yanyan Yin Yanyan Yin Xiaojian Zhang Xiaojian Zhang Cascade catalytic nanoplatform for enhanced starvation and sonodynamic therapy Taylor & Francis Group 2019 Catalytic reaction manganese dioxide nanoparticles starvation therapy sonodynamic therapy magnetic resonance imaging 2019-08-01 10:11:02 Journal contribution https://tandf.figshare.com/articles/journal_contribution/Cascade_catalytic_nanoplatform_for_enhanced_starvation_and_sonodynamic_therapy/9205199 <p><b>Background:</b> Sonodynamic therapy (SDT) has emerged as an alternative to the traditional treatments of cancer. However, the oxygen consumption induced by SDT and glucose oxidase (GOx) mediated starvation therapy would worsen the hypoxic tumor environment, which further impeded therapeutic efficacy. </p> <p><b>Purpose:</b> To develop a nanoplatform and investigate its anti-cancer mechanism for enhanced starvation and SDT.</p> <p><b>Methods:</b> We constructed a cascade catalytic nanoplatform based on GOx modified the mesoporous MnO<sub>2</sub> NPs loaded with hematoporphyrin monomethyl ether (HMME), which were designated as GOx-MnO<sub>2</sub>/HMME. We characterized them for their catalytic activity, and investigate the magnetic resonance imaging and anti-tumor efficiency in vitro and in vivo.</p> <p><b>Results:</b> MnO<sub>2</sub> NPs with catalase-like activity could oxidize H<sub>2</sub>O<sub>2</sub> under acid condition to produce O<sub>2</sub>, which not only in turn was supplied to the glucose-depletion reaction for an efficient starvation therapy, but also enhanced the <sup>1</sup>O<sub>2</sub> generation for HMME mediated SDT effect. In addition, the released Mn<sup>2+</sup> ions in the system were able to enhance the MRI signal. Both <i>in vitro</i> and <i>in vivo</i> experiments suggested the cascade catalytic-therapeutic effect between GOx, MnO<sub>2</sub> NPs and HMME, demonstrating the enhanced starvation and SDT.</p>