10.6084/m9.figshare.9609422.v1
Shen Sheng
Shen
Sheng
Wang Jiwen
Wang
Jiwen
Zhang Dexiang
Zhang
Dexiang
Zheng Bohao
Zheng
Bohao
Wang Yueqi
Wang
Yueqi
Liu Han
Liu
Han
Ni Xiaoling
Ni
Xiaoling
Suo Tao
Suo
Tao
Houbao Liu
Houbao
Liu
DMBT1 suppresses progression of gallbladder carcinoma through PI3K/AKT signaling pathway by targeting PTEN
Taylor & Francis Group
2019
Gallbladder carcinoma
DMBT1
PTEN
PI3K/AKT
2019-08-14 09:41:55
Dataset
https://tandf.figshare.com/articles/dataset/DMBT1_suppresses_progression_of_gallbladder_carcinoma_through_PI3K_AKT_signaling_pathway_by_targeting_PTEN/9609422
<p>Gallbladder carcinoma (GBC) is a highly lethal malignancy of the gastrointestinal tract. Despite extensive research, the underlying molecular mechanism of GBC remains largely unclear. Deleted in malignant brain tumors 1 (DMBT1) is low-expression during cancer progression and as a potential tumor-suppressor gene in various types of cancer. However, its role in Gallbladder cancer remains poorly understood. Here, we found that DMBT1 was significantly low-expression and deletion of copy number in GBC tissues by qRT-PCR and Western blot. Overexpression of DMBT1 impaired survival, promoted apoptosis in GBC cells <i>in vitro</i>, and inhibited tumor progression <i>in vivo</i>. Further study of underlying mechanisms demonstrated that DMBT1 combined with PTEN which could stabilize PTEN protein, resulting in inhibiting the activation of PI3K/AKT signaling pathway. Our study revealed a new sight of DMBT1 as a tumor-suppressor gene on the PI3K/AKT pathway in GBC, which may be a potential therapeutic target for improving treatment.</p> <p>Down-regulation of DMBT1 suppresses progression of gallbladder carcinoma through PI3K/AKT signaling pathway activation by targeting PTEN.
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