Sheng, Shen Jiwen, Wang Dexiang, Zhang Bohao, Zheng Yueqi, Wang Han, Liu Xiaoling, Ni Tao, Suo Liu, Houbao DMBT1 suppresses progression of gallbladder carcinoma through PI3K/AKT signaling pathway by targeting PTEN <p>Gallbladder carcinoma (GBC) is a highly lethal malignancy of the gastrointestinal tract. Despite extensive research, the underlying molecular mechanism of GBC remains largely unclear. Deleted in malignant brain tumors 1 (DMBT1) is low-expression during cancer progression and as a potential tumor-suppressor gene in various types of cancer. However, its role in Gallbladder cancer remains poorly understood. Here, we found that DMBT1 was significantly low-expression and deletion of copy number in GBC tissues by qRT-PCR and Western blot. Overexpression of DMBT1 impaired survival, promoted apoptosis in GBC cells <i>in vitro</i>, and inhibited tumor progression <i>in vivo</i>. Further study of underlying mechanisms demonstrated that DMBT1 combined with PTEN which could stabilize PTEN protein, resulting in inhibiting the activation of PI3K/AKT signaling pathway. Our study revealed a new sight of DMBT1 as a tumor-suppressor gene on the PI3K/AKT pathway in GBC, which may be a potential therapeutic target for improving treatment.</p> <p>Down-regulation of DMBT1 suppresses progression of gallbladder carcinoma through PI3K/AKT signaling pathway activation by targeting PTEN. </p> Gallbladder carcinoma;DMBT1;PTEN;PI3K/AKT 2019-08-14
    https://tandf.figshare.com/articles/dataset/DMBT1_suppresses_progression_of_gallbladder_carcinoma_through_PI3K_AKT_signaling_pathway_by_targeting_PTEN/9609422
10.6084/m9.figshare.9609422.v1