10.6084/m9.figshare.9611672.v1 Guo-Hua Ye Guo-Hua Ye Jun-Juan Xue Jun-Juan Xue Wei-Ling Liang Wei-Ling Liang Shou-Juan Yang Shou-Juan Yang Three new bioactive diterpenoids from the roots of <i>Croton crassifolius</i> Taylor & Francis Group 2019 Croton crassifolius halimane diterpenoids clerodane diterpenoids NO production single-crystal X-ray diffraction 2019-08-14 11:15:40 Journal contribution https://tandf.figshare.com/articles/journal_contribution/Three_new_bioactive_diterpenoids_from_the_roots_of_i_Croton_crassifolius_i_/9611672 <p>Phytochemical investigation of <i>Croton crassifolius</i> led to the isolation of two new halimane diterpenoids (<b>1</b> and <b>2</b>), a new <i>nor</i>-clerodane diterpenoid (<b>3</b>), along with three known analogues (<b>4</b>–<b>6</b>). Their structures including absolute configurations were elucidated by spectroscopic analysis, single-crystal X-ray diffraction, and CD analysis. All isolates were evaluated for their inhibitory effects on the nitric oxide (NO) production induced by lipopolysaccharide (LPS) in RAW264.7 macrophage cells, and compound <b>1</b> exhibited moderate inhibition of NO production with an IC<sub>50</sub> value of 25.8 ± 0.9 <i>μ</i>M.</p>