10.6084/m9.figshare.9611672.v1
Guo-Hua Ye
Guo-Hua
Ye
Jun-Juan Xue
Jun-Juan
Xue
Wei-Ling Liang
Wei-Ling
Liang
Shou-Juan Yang
Shou-Juan
Yang
Three new bioactive diterpenoids from the roots of <i>Croton crassifolius</i>
Taylor & Francis Group
2019
Croton crassifolius
halimane diterpenoids
clerodane diterpenoids
NO production
single-crystal X-ray diffraction
2019-08-14 11:15:40
Journal contribution
https://tandf.figshare.com/articles/journal_contribution/Three_new_bioactive_diterpenoids_from_the_roots_of_i_Croton_crassifolius_i_/9611672
<p>Phytochemical investigation of <i>Croton crassifolius</i> led to the isolation of two new halimane diterpenoids (<b>1</b> and <b>2</b>), a new <i>nor</i>-clerodane diterpenoid (<b>3</b>), along with three known analogues (<b>4</b>–<b>6</b>). Their structures including absolute configurations were elucidated by spectroscopic analysis, single-crystal X-ray diffraction, and CD analysis. All isolates were evaluated for their inhibitory effects on the nitric oxide (NO) production induced by lipopolysaccharide (LPS) in RAW264.7 macrophage cells, and compound <b>1</b> exhibited moderate inhibition of NO production with an IC<sub>50</sub> value of 25.8 ± 0.9 <i>μ</i>M.</p>