Anti-inflammatory and cytotoxic agents from <i>Xylaria</i> sp. SWUF09-62 fungus
Theerawat Patjana
Phongphan Jantaharn
Praewpan Katrun
Wiyada Mongkolthanaruk
Nuttika Suwannasai
Thanaset Senawong
Sarawut Tontapha
Vittaya Amornkitbumrung
Sirirath McCloskey
10.6084/m9.figshare.9638447.v1
https://tandf.figshare.com/articles/journal_contribution/Anti-inflammatory_and_cytotoxic_agents_from_i_Xylaria_i_sp_SWUF09-62_fungus/9638447
<p>The ongoing search for anti-cancer agents from microorganisms led to the isolation of four new compounds including 6-ethyl-8-hydroxy-4<i>H</i>-chromen-4-one (<b>1</b>), 6-ethyl-7,8-dihydroxy-4<i>H</i>-chromen-4-one (<b>2</b>), (3<i>S</i>)-3,4-dihydro-8-hydroxy-7-methoxy-3-methylisocoumarin (<b>3</b>) and (3<i>S</i>)-3,4-dihydro-5,7,8-trihydroxy-3-methylisocoumarin (<b>4</b>), together with eleven known compounds (<b>5</b>–<b>15</b>) from <i>Xylaria</i> sp. SWUF09-62 fungus. The chemical structures were deduced from IR, 1D and 2D NMR, and MS data. The absolute configurations of <b>3</b> and <b>4</b> were determined by ECD experiment. Compounds <b>2</b> and <b>4</b> indicated possible chemo-prevention and chemo-therapeutic properties, exhibited anti-inflammatory properties by reducing nitric oxide production in LPS-stimulated RAW264.7 cells (IC<sub>50</sub> = 1.57 ± 0.25 and 3.02 ± 0.27 <i>μ</i>g/mL) and cytotoxicity against HT29 cells (IC<sub>50</sub> = 16.46 ± 0.48 and 97.78 ± 7.14 <i>μ</i>g/mL).</p> <p></p>
2019-08-16 11:06:55
Anti-inflammatory
chromone
cytotoxicity
mellein
nitric oxide (NO)
Xylaria