Two novel diterpenes from the stems and leaves of tropical seagrass <i>Enhalus acoroides</i> in the South China sea Xiao-Bing Wang Zhong-Hao Sun Li-Xia Fan Yang-Yang Liu Jian Feng Guo-Xu Ma De-Li Chen 10.6084/m9.figshare.9691697.v1 https://tandf.figshare.com/articles/journal_contribution/Two_novel_diterpenes_from_the_stems_and_leaves_of_tropical_seagrass_i_Enhalus_acoroides_i_in_the_South_China_sea/9691697 <p>Two novel diterpenes Enhoidin A (<b>1</b>) and Enhoidin B (<b>2</b>) featuring an unusual gibberellane skeleton were isolated from the stems and leaves of <i>Enhalus acoroides</i>. Their structures were elucidated on the basis of spectroscopic analysis including 1D and 2D NMR techniques and HR-ESI-MS. This is the first time that this type of lactone ring between C-18 and C-20 has been found among gibberellanes from the tropical seagrasses. Evaluation of the all compounds for cytotoxicity against four human cancer cell lines (MCF-7, HCT-116, HepG-2 and HeLa), and showed moderate cytotoxic activities.</p> 2019-08-20 11:44:36 Tropical seagrass Enhalus acoroides diterpene cytotoxic activity